Email this article СOLORECTAL CANCER AND INCULIN-LIKE GROWTH FACTORS
- Authors: Nikolayev A.A.1, Gerstein E.S.1, Korotkova E.A.1, Delektorskaya V.V.1, Dvorova E.K.1
-
Affiliations:
- N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
- Issue: Vol 2, No 2 (2013)
- Pages: 13-16
- Section: IN FOCUS
- Published: 28.02.2015
- URL: https://onco-surgery.info/jour/article/view/69
- DOI: https://doi.org/10.17650/2220-3478-2013-0-2-13-16
- ID: 69
Cite item
Full Text
Abstract
Insulin-like growth factors (IGF) 1 and 2 and IGF binding proteins (IGFBP) 1 and 3 levels were measured by ELISA techniques in blood serum of 74 primary colorectal cancer (СRC) patients and 30 control practically healthy persons. Significant increase of IGF-1 level and decrease of IGFBP-3 level were demonstrated in patients’ serum as compared to control group. Sensitivity of IGF-1 as a prospective diagnostic СRС marker comprised 80 % with 75 % specificity using 140 ng/ml as cut-off level. Significant negative association was found be-tween both patients and donors’ age and serum IGF-1 levels, but in CRC patients it was much weaker than in control group. No associations were found between serum IGF 1 and 2 levels and main criteria of colorectal cancer progression.
Keywords
About the authors
A. A. Nikolayev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: esgershtein@gmail.com
Russian Federation
E. S. Gerstein
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Author for correspondence.
Email: esgershtein@gmail.com
Russian Federation
E. A. Korotkova
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: esgershtein@gmail.com
Russian Federation
V. V. Delektorskaya
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: esgershtein@gmail.com
Russian Federation
E. K. Dvorova
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: esgershtein@gmail.com
Russian Federation
References
Supplementary files
