Proton beam therapy for rectal cancer: a literature review

Cover Page

Cite item

Full Text

Abstract

Colorectal cancer is a significant group of malignant neoplasms that dominates the morbidity and mortality patterns in the world. for patients with colorectal cancer, a multidisciplinary approach is required when choosing treatment tactics involving surgeons, radiotherapists and chemotherapists. At present, it is impossible to overestimate the role of radiotherapy in the treatment of locally advanced rectal cancer. The purpose of this review is to summarize current data on proton beam therapy and its role in the treatment of rectal cancer.

About the authors

I. V. Kozlova

Federal Scientific Clinical Center for Medical Radiology and Oncology of the Federal Medical Biological Agency; Ulyanovsk State University

Author for correspondence.
Email: kozlovaiv@fvcmrfmba.ru

Irina valerievna Kozlova

5v Kurchatov St., Dimitrovgrad 433507

42 Lev Tolstoy St., Ulyanovsk 432017

Russian Federation

Yu. D. Udalov

Federal Scientific Clinical Center for Medical Radiology and Oncology of the Federal Medical Biological Agency

Email: fake@neicon.ru

5v Kurchatov St., Dimitrovgrad 433507

Russian Federation

L. A. Danilova

Federal Scientific Clinical Center for Medical Radiology and Oncology of the Federal Medical Biological Agency

Email: fake@neicon.ru

5v Kurchatov St., Dimitrovgrad 433507

Russian Federation

A. V. Nezvetsky

Federal Scientific Clinical Center for Medical Radiology and Oncology of the Federal Medical Biological Agency

Email: fake@neicon.ru

5v Kurchatov St., Dimitrovgrad 433507

Russian Federation

I. A. Bogomolova

Federal Scientific Clinical Center for Medical Radiology and Oncology of the Federal Medical Biological Agency

Email: fake@neicon.ru

5v Kurchatov St., Dimitrovgrad 433507

Russian Federation

S. E. Gritsenko

Federal Scientific Clinical Center for Medical Radiology and Oncology of the Federal Medical Biological Agency

Email: fake@neicon.ru

5v Kurchatov St., Dimitrovgrad 433507

Russian Federation

References

  1. URL: https://cr.minzdrav.gov.ru/recomend/554_3. Rectal cancer. Clinical Guidelines, 2022. (In Russ.).
  2. Gérard A., Buyse M., Nordlinger B. et al. Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC). Ann Surg 1988;208(5):606–14. doi: 10.1097/00000658-198811000-00011
  3. Cedermark B., Dahlberg M., Glimelius B. et al. Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 1997;336:980–7. doi: 10.1056/NEJM199704033361402
  4. Sauer R., Becker H., Hohenberger W. et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004;351:1731–40. doi: 10.1056/NEJMoa040694
  5. Nicholas S., Chen L., Choflet A. et al. Pelvic Radiation and normal tissue toxicity. Seminars in Radiation Oncology 2017;27(4):358–69. doi: 10.1016/j.semradonc.2017.04.010
  6. Van Gijn W., Marijnen C.A., Nagtegaal I.D. et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomized controlled TME trial. Lancet Oncol 2011;12(6):575–82. doi: 10.1016/S1470-2045(11)70097-3
  7. Moriya Y., Akasu T., Fujita S. et al. Total pelvic exenteration with distal sacrectomy for fixed recurrent rectal cancer. Surg Oncol Clin N Am 2005;14:225–38. doi: 10.1016/j.soc.2004.11.014
  8. Tao R., Tsai C.J., Jensen G., Eng C. et al. Hyperfractionated accelerated reirradiation for rectal cancer: An analysis of outcomes and toxicity. Radiother Oncol 2017;122(1):146–51. doi: 10.1016/j.radonc.2016.12.015
  9. Zabelin M.V., Klimanov V.A., Galyautdinova Zh.Zh. et al. Proton radiation therapy: clinical application possibilities and research prospects. Research and practice in medicine 2018;5(1):82–95. (In Russ.). doi: 10.17709/2409-2231-2018-5-1-10
  10. Baliga S., Yock T.I. Proton beam therapy in pediatric oncology. Curr Opin Pediatr 2019;31(1):28–34.
  11. Gordon K.B., Smyk D.I., Gulidov I.А. Proton therapy in head and neck cancer treatment: state of the problem and development prospects (review). Modern technologies in medicine 2021;13(4):70–81. (In Russ.). doi: 10.17691/stm2021.13.4.08
  12. Haque W., Butler E.B., Teh B.S. Stereotactic body radiation therapy for prostate cancer-a review. Chin Clin Oncol 2017; 6(Suppl 2):10. doi: 10.21037/cco.2017.06.05
  13. Rusňák Š., Hecová L., Kasl Z. et al. Therapy of uveal melanoma A Review. Cesk Slov Oftalmol 2020;77(1):1–13. doi: 10.31348/2020/10
  14. Udalov Yu.D., Samoilov A.S., Danilova L.A. et al. Modern treatment of non-small cell lung cancer with intracerebral metastases and metastatic lesions of the liver, mediastinal lymph nodes, skeletal bones. Clinical observation. Мedical Radiology and Radiation Safety 2021;66(3):82–7. (In Russ.). doi: 10.12737/1024-6177-2021-66-3-82-87
  15. Udalov Yu.D., Zlobina E.L., Danilova L.A. et al. The possibilities of proton therapy for repeated irradiation of diffuse brain stem tumors in children. Extreme medicine 2021;23(4):65–71. (In Russ.). doi: 10.47183/mes.2021.039
  16. Udalov Yu.D., Nezvetsky A.V., Danilova L.A. et al. Analysis of the results of proton radiation therapy in patients with squamous cell carcinoma of the head and neck. Journal of oncology: diagnostic radiology and radiotherapy 2022;5(3):9–17. (In Russ.). doi: 10.37174/2587-7593-2022-5-3-9-17
  17. Pan’shin G.A., Tsallagova Z.S., Izmailov T.R. Radiotherapy of Malignant Tumors: Photons or Protons? Part 1. Bragg Peak and the Brief Characteristics of a Proton Beam. Journal of radiology and nuclear medicine 2020;101(6):369–72. (In Russ.). doi: 10.20862/0042-4676-2020-101-6-369-372
  18. Pryanichnikov A.A., Chernyaev A.P., Khoroshkov V.S. Introduction to physics and proton therapy technique. Study guide. Series “Library of Medical physicist”. Moscow: OOP of the Faculty of Physics of Moscow State University, 2019. 104 р. (In Russ.).
  19. Parzen J.S., Zheng W., Li X. et al. Optimization of field design in the treatment of rectal cancer with intensity modulated proton beam radiation therapy: how many fields are needed to account for rectal distension uncertainty? Adv Radiat Oncol 2021;6(5):100749. doi: 10.1016/j.adro.2021.100749
  20. Colaco R.J., Nichols R.C., Huh S et al. Protons offer reduced bone marrow, small bowel, and urinary bladder exposure for patients receiving neoadjuvant radiotherapy for resectable rectal cancer. J Gastrointest Oncol 2014;5:3–8. doi: 10.3978/j.issn.2078-6891.2013.041
  21. Wolff H.A., Wagner D.M., Conradi L.C. et al. Irradiation with protons for the individualized treatment of patients with locally advanced rectal cancer: A planning study with clinical implications. Radiother Oncol 2012;102:30–7. doi: 10.1016/j.radonc.2011.10.018
  22. Jeans E.B., Jethwa K.R., Harmsen W.S. et al. Clinical implementation of preoperative short-course pencil beam scanning proton therapy for patients with rectal cancer. Adv Radiat Oncol 2020;5(5):865–70. doi: 10.1016/j.adro.2020.05.004
  23. Kronborg C.J.S., Jørgensen J.B., Petersen J.B.B. et al. Pelvic insufficiency fractures, dose volume parameters and plan optimization after radiotherapy for rectal cancer. Clin Transl Radiat Oncol 2019;19:72–6. doi: 10.1016/j.ctro.2019.09.001
  24. Rønde H.S., Kallehauge J.F., Kronborg C.J.S. et al. Intensity modulated proton therapy planning study for organ at risk sparing in rectal cancer re-irradiation. Acta Oncologica 2021;60(11):1436–9. doi: 10.1080/0284186X.2021.1953139
  25. Hamauchi S., Yamazaki K., Yasui H. et al. Safety and efficacy of proton-beam radiation therapy for patients with locally recurrent rectal cancer. Ann Oncol 2012;23:xi132–67. doi: 10.1016/S0923-7534(20)32506-0
  26. Fok M., Toh S., Easow J. et al. Proton beam therapy in rectal cancer: A systematic review and meta-analysis. Surg Oncol 2021;38:101638. doi: 10.1016/j.suronc.2021.101638
  27. Koroulakis A., Molitoris J., Kaiser A. el al. Reirradiation for rectal cancer using pencil beam scanning proton therapy: a single institutional experience. Adv Radiat Oncol 2021;6(1):100595. doi: 10.1016/j.adro.2020.10.008
  28. Moningi S., Ludmir E.B., Polamraju P. Definitive hyperfractionated, accelerated proton reirradiation for patients with pelvic malignancies. Clin Transl Radiat Oncol 2019;19:59–65. doi: 10.1016/j.ctro.2019.08.004
  29. Hiroshima Y., Ishikawa H., Murakami M. et al. Proton beam therapy for local recurrence of rectal cancer. Anticancer Res 2021;41(7):3589–95. doi: 10.21873/anticanres.15147
  30. Hee Cheol Kim, Samsung Medical Center, Korea. Identifier: NCT03098108. URL: ClinicalTrials.gov.
  31. Dae Yong Kim, National Cancer Center, Korea. Identifier: NCT03566355. URL: ClinicalTrials.gov.
  32. Dae Yong Kim, National Cancer Center, Korea. Identifier: NCT03577665. URL: ClinicalTrials.gov.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c)


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 85909 от  25.08.2023.