Email this article Role of microsatellite instability in colon cancer
- Authors: Fedyanin M.Y.1, Tryakin A.A.1, Tjulandin S.A.1
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Affiliations:
- N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
- Issue: Vol 1, No 3 (2012)
- Pages: 19-25
- Section: REVIEW
- Published: 28.02.2015
- URL: https://onco-surgery.info/jour/article/view/49
- DOI: https://doi.org/10.17650/2220-3478-2012-0-3-321-338
- ID: 49
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Abstract
Coloncancer is among leading causes of cancer morbidity and mortality both inRussiaand worldwide. Development of molecular biology lead to decoding of carcinogenesis and tumor progression mechanisms. These processes require accumulation of genetic and epigenetic alterations in a tumor cell.Coloncancer carcinogenesis is characterized by mutations cumulation in genes controlling growth and differentiation of epithelial cells, which leads to their genetic instability. Microsatellite instability is a type of genetic instability characterized by deterioration of mismatch DNA repair. This leads to faster accumulation of mutations in DNA. Loss of mismatch repair mechanism can easily be diagnosed by length of DNA microsatellites. These alterations are termed microsatellite instability. They can be found both in hereditary and sporadic colon cancers. This review covers the questions of microsatellite instability, its prognostic and predictive value in colon cancer.
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About the authors
M. Yu. Fedyanin
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Author for correspondence.
Email: fedianinmu@mail.ru
Russian Federation
A. A. Tryakin
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
S. A. Tjulandin
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
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