Email this article Development of a new metronidazole delivery form and its clinical use in complex treatment of rectal cancer
- Authors: Barsukov Y.A.1, Tkachev S.I.1, Oltarzhevskaya N.D.1, Kuzmichev D.V.1, Gordeyev S.S.1
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Affiliations:
- N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
- Issue: Vol 1, No 3 (2012)
- Pages: 11-18
- Section: IN FOCUS
- Published: 28.02.2015
- URL: https://onco-surgery.info/jour/article/view/48
- DOI: https://doi.org/10.17650/2220-3478-2012-0-3-11-18
- ID: 48
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Abstract
A review of russian and foreign literature concerning clinical use of metronidazole as a radiosensitizer in oncologic treatment. New delivery form of metronidazole has been developed using a polymeric composition. Dose- and time-dependent pharmacodynamics has been analyzed. Personal long-term results of complex treatment of localized and locally-advanced rectal cancer using different radiosensitizers has been presented. The data allows to consider complex treatment as a method of choice for these patients. Using polyradiomodification allowed to decrease lymphohematogenic metastasing rate, decrease locoregional recurrence rate and improve disease-free survival.
About the authors
Yu. A. Barsukov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
S. I. Tkachev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
N. D. Oltarzhevskaya
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
D. V. Kuzmichev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Author for correspondence.
Email: veritas_dk@mail.ru
Russian Federation
S. S. Gordeyev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: fake@neicon.ru
Russian Federation
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