Email this article Development of a new metronidazole delivery form and its clinical use in complex treatment of rectal cancer
- Authors: Barsukov Y.A.1, Tkachev S.I.1, Oltarzhevskaya N.D.1, Kuzmichev D.V.1, Gordeyev S.S.1
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Affiliations:
- N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
- Issue: Vol 1, No 3 (2012)
- Pages: 11-18
- Section: IN FOCUS
- Published: 28.02.2015
- URL: https://onco-surgery.info/jour/article/view/48
- DOI: https://doi.org/10.17650/2220-3478-2012-0-3-11-18
- ID: 48
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Abstract
A review of russian and foreign literature concerning clinical use of metronidazole as a radiosensitizer in oncologic treatment. New delivery form of metronidazole has been developed using a polymeric composition. Dose- and time-dependent pharmacodynamics has been analyzed. Personal long-term results of complex treatment of localized and locally-advanced rectal cancer using different radiosensitizers has been presented. The data allows to consider complex treatment as a method of choice for these patients. Using polyradiomodification allowed to decrease lymphohematogenic metastasing rate, decrease locoregional recurrence rate and improve disease-free survival.
About the authors
Yu. A. Barsukov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowRussian Federation
S. I. Tkachev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowRussian Federation
N. D. Oltarzhevskaya
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowRussian Federation
D. V. Kuzmichev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Author for correspondence.
Email: veritas_dk@mail.ru
Russian Federation
S. S. Gordeyev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowRussian Federation
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