Email this article Role of antiangiogenic agents in the treatment of metastatic colorectal cancer
- Authors: Zabelin M.V.1, Gordeev S.S.2, Petrov L.O.3, Kostin A.A.4, Varlamova S.E.5
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Affiliations:
- Federal Medical and Biological Agency of Russia
- N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
- P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of Russia
- National Medical Radiology Research Center, Ministry of Health of Russia
- State Research Center – Burnasyan Federal Medical Biophysical Center, Federal Medical and Biological Agency of Russia
- Issue: Vol 8, No 1 (2018)
- Pages: 11-18
- Section: REVIEW
- Published: 29.05.2018
- URL: https://onco-surgery.info/jour/article/view/238
- DOI: https://doi.org/10.17650/2220-3478-2018-8-1-11-18
- ID: 238
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Abstract
This review covers the latest data on antiangiogenic agents used in patients with colorectal cancer. In this article, we describe drugs that have already been included into therapy regimens for colorectal cancer and vascular endothelial growth factor (VEGF) inhibitors that have been approved for other indications. Targeted drugs with a similar mechanism of action that are currently in clinical trials are discussed separately. VEGF-inhibitors are one of the main groups of targeted drugs for colorectal cancer with an acceptable toxicity profile, which can be used both in combination with chemotherapeutic agents and as maintenance treatment. Moreover, these drugs are not dependent on mutational status, which is a significant advantage.
About the authors
M. V. Zabelin
Federal Medical and Biological Agency of Russia
Author for correspondence.
Email: maximzabelin@mail.ru
Russian Federation
S. S. Gordeev
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Email: fake@neicon.ru
Russian Federation
L. O. Petrov
P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of Russia
Email: fake@neicon.ru
Russian Federation
A. A. Kostin
National Medical Radiology Research Center, Ministry of Health of Russia
Email: fake@neicon.ru
ORCID iD: 0000-0002-0792-6012
Russian Federation
S. E. Varlamova
State Research Center – Burnasyan Federal Medical Biophysical Center, Federal Medical and Biological Agency of Russia
Email: fake@neicon.ru
Russian Federation
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