Vol 6, No 1 (2016)

Surgery and Oncology. 2016;6(1):7

ORIGINAL REPORTS

Colorectal cancer with synchronous lung metastases: clinical characteristics, treatment, prognosis

Rasulov A.O., Davydov M.M., Aliev V.A., Gordeev S.S., Allakhverdiev A.K., Akhmedov B.B., Nalbandyan A.V.

Abstract

Surgery and Oncology. 2016;6(1):8-13

8-13

Analysis of the histological pattern, growth rates, and nature of metastases from complicated colorectal cancer

Shchaeva S.N., Narezkin D.V., Solov’ev V.I.

Abstract

Surgery and Oncology. 2016;6(1):14-21

14-21

Features a combined surgical treatment in preserving the quality of life in patients with invasive colorectal cancer

Abduzhapparov S.B., Matniyozova S.Y.

Abstract

Background. The aim of the work was to study the effect of combined surgical treatment of locally advanced rectal cancer (RC) with the invasion of the organs of the female reproductive system on the quality of life of patients.

Materials and methods. Presents the diagnosis and treatment of 134 patients with the RC in age from 21 to 70 years, with the invasion of the organs of the female reproductive system. All patients carried the standard clinical and laboratory tests.

Results. Half of the patients (50.7 % of cases) T4N1M0 stage of the disease has been diagnosed. In 75 (56.0 %) patients with tumor spread into the vagina, and in 16 (11.9 %) patients – just a few of the reproductive system. In the study group of 64 patients with the RC, along with surgery on the rectum, combined organ-performed surgery reproductive organs. In the control group all 70 patients was performed hysterectomy with appendages.

Conclusions. Quality of life according to the questionnaire MENQOL, was significantly higher in patients with organ-treatment, which showed a decrease in vasomotor and psychological symptoms, as well as smoothing of irregularities in the physical and sexual spheres. Studies have show the validity of the widespread introduction in the oncological practice combined simultaneous operations that preserve the reproductive organs in women with invasive RC, which is especially important for women of reproductive age.

Surgery and Oncology. 2016;6(1):22-26

22-26

REVIEW

Metronomic chemotherapy regimens in oncology

Fedyanin M.Y., Pokataev I.A., Tyulyandin S.A.

Abstract

Metronomic chemotherapy implies the regular use of cytotoxic agents in doses much smaller than the maximum tolerable doses for a long time. Preclinical experiments show that this treatment option has a many-sided (antiangiogenic, immunostimulating, and direct cytotoxic) effect on tumor. Moreover, this approach has gained the widest acceptance in treating patients with metastatic breast cancer in clinical practice. By taking into account the high activity of angiogenesis in colon cancer progression, it is interesting to study the impact of metronomic chemotherapy regimens for this nosological entity as well. This literature review considers not only the history of metronomic chemotherapy, the mechanisms of action, and a range of drugs having an antitumor effect in the metronomic regimens, but also analyzes clinical trials of metronomic chemotherapy regimens in patients with metastatic colon cancer.

Surgery and Oncology. 2016;6(1):27-35

27-35

Transanal surgery in the treatment of rectal tumors

Mel’nikov P.V., Savenkov S.V., Kanner D.Y., Eres’ko D.V., Tamrazov R.I.

Abstract

In last two decades, transanal endoscopic microsurgery (TEM) in treatment of both benign and malignant tumor of rectum is actively developing. The aim of this review was to describe the current status of transanal interventions. Due to the low level of recurrens (mean about 6 %) TEM has become the method of choice for removal of rectal adenomas. Several studies have demonstrated the benefits of treatment TEM in cases of early T1 cancer compared to conventional resection. However, for more invasive adenocarcinomas performing TEM remains controversial, but it’s very promising method for the complex treatment. Just as transanal mesorectal exision in treatment of mid- and low rectal cancer as a new strategy – natural orifice transluminal surgery. However, it lack of evidence base and international experience in small series presented, so large randomized trials is needed.

Surgery and Oncology. 2016;6(1):36-42

36-42

Minimally invasive methods of local treatment for colorectal cancer liver metastases: state-of-the art (a review of literature)

Abdulaev M.A., Napol’skaya E.V., Tsikoridze M.Y.

Abstract

The paper reviews the data available in modern Russian and foreign literature on the existing minimally invasive methods of local exposure of colorectal cancer liver metastases, which include ablation procedures (radiofrequency ablation, laser thermal ablation, and cryoablation), stereotactic radiotherapy and radiosurgery, as well as X-ray endovascular procedures (chemoinfusion, chemoembolization, and radioembolization). The characteristics of some treatment options and a surgical procedure, as well as those of each other were compared.

Surgery and Oncology. 2016;6(1):43-47

43-47

CASE REPORT

Simultaneous laparoscopic and thoracoscopic intervention for lung metastases from rectal cancer (a clinical case)

Davydov M.I., Davydov M.M., Rasulov A.O., Allakhverdiev A.K., Kuz’michev D.V., Polynovskiy A.V., Suraeva Y.E.

Abstract

The paper describes a clinical case of successful treatment in a female patient with disseminated rectal cancer by minimally invasive technologies that could perform one-stage simultaneous intervention into the rectum and lung, which promoted rapid patient rehabilitation and reduced systemic chemotherapy initiation time.

Surgery and Oncology. 2016;6(1):48-52

48-52