ДАННЫЕ ИССЛЕДОВАНИЙ ПРИ КRAS- И RAS-НЕМУТИРОВАННОМ (ДИКОМ) ТИПЕ КОЛОРЕКТАЛЬНОГО РАКА

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Аннотация

В статье приводится анализ последних исследований, сравнивающих режимы лекарственной терапии, включающих антиEGFR моноклональные антитела,  с теми же режимами химиотерапии (ХТ)  с бевацизумабом. Данные этих исследований неоднозначны, однако обстоятельный анализ исследования FIRE-3 позволяет выделить подгруппы пациентов с предпочти- тельным назначением в качестве 1-й линии лечения метастатического колоректального рака с отсутствием мутации гена RAS (RAS дикого типа) схем ХТ в сочетании с цетуксимабом либо панитумумабом. Ожидается окончательный анализ данной категории пациентов в исследовании CALGB/SWOG 80 405. Обязательным является исследование опухолей на мутацию RAS для выбора 1-й линии.

Об авторах

В. А. Горбунова

ФГБНУ «РОНЦ им. Н.Н. Блохина»

Автор, ответственный за переписку.
Email: veragorbounova@mail.ru

ФГБНУ «РОНЦ им. Н.Н. Блохина»; Россия, 115 478, Москва, Каширское шоссе, 24

 

Россия

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