Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press9810.17650/2220-3478-2013-0-4-12-22REVIEWОБЗОРЫ ЛИТЕРАТУРЫBIOLOGICAL MARKERS OF RECTAL CANCER NEOADJUVANT CHEMORADIOTHERAPY EFFICACYБИОЛОГИЧЕСКИЕ МАРКЕРЫ ЭФФЕКТИВНОСТИ ПРЕДОПЕРАЦИОННОЙ ХИМИОЛУЧЕВОЙ ТЕРАПИИ МЕСТНО-РАСПРОСТРАНЕННОГО РАКА ПРЯМОЙ КИШКИFedyaninM. Yu.ФедянинМ. Ю.
Russian Federation

Department of Clinical Pharmacology and Chemotherapy

Отделение клинической фармакологии и химиотерапии

fedianinmu@mail.ruTryakinA. A.ТрякинА. А.
Russian Federation

Department of Clinical Pharmacology and Chemotherapy

Отделение клинической фармакологии и химиотерапии

fedianinmu@mail.ruTjulandinS. A.ТюляндинС. А.
Russian Federation

Department of Clinical Pharmacology and Chemotherapy

Отделение клинической фармакологии и химиотерапии

fedianinmu@mail.ruN.N. Blokhin Russian Cancer Research Center,Russian Academy of Medical Sciences, MoscowФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва271220132412220103201501032015Copyright ©; 2013, ABV-pressCopyright ©; 2013, АБВ-пресс2013ABV-pressАБВ-прессhttps://onco-surgery.info/jour/about/editorialPolicieshttps://onco-surgery.info/jour/article/view/98

Combination of neoadjuvant chemoradiotherapy and surgery is the basic treatment for locally advanced rectal tumors. Despite that, a subgroup of patients does not benefit from combined treatment. A wide search of biological markers predicting neoadjuvant chemoradiotherapy efficacy is currently conducted. Tumor cell signal pathways are investigated (EGFR, Wnt), cell cycle and apoptosis, tumor stroma. Several studies with DNA microarray analysis were conducted. Predictive value of these biological markers is reviewed in this article.

Сочетание хирургического и предоперационного химиолучевого лечения является основой лечебной тактики больных местно-распространенным раком прямой кишки. Тем не менее у ряда пациентов не удается достигнуть ответа на лечение. В настоящее время широко проводится поиск биологических маркеров эффективности предоперационной химиолучевой терапии при местно-распространенном раке прямой кишки. Уделяется внимание компонентам различных сигнальных путей опухолевой клетки (EGFR-путь, Wnt-путь), клеточного цикла и апоптоза, стромы опухоли. Проведено несколько исследований с применением микрочипирования ДНК. В настоящей обзорной статье рассматривается предикторное значение данных биологических маркеров.

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