Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press8310.17650/2220-3478-2014-0-4-8-15REVIEWОБЗОРЫ ЛИТЕРАТУРЫFIRST-LINE TREATMENT IN PATIENTS WITH INOPERABLE METASTATIC COLON CANCERПЕРВАЯ ЛИНИЯ ЛЕЧЕНИЯ БОЛЬНЫХ МЕТАСТАТИЧЕСКИМ НЕОПЕРАБЕЛЬНЫМ РАКОМ ТОЛСТОЙ КИШКИFedyaninM. Yu.ФедянинМ. Ю.
Russian Federation
fedianinmu@mail.ruTryakinA. A.ТрякинА. А.
Russian Federation
fedianinmu@mail.ruTjulandinS. A.ТюляндинС. А.
Russian Federation
fedianinmu@mail.ruN.N. Blokhin Russian Cancer Research Center, MoscowФГБНУ «РОНЦ им. Н.Н. Блохина», Москва28122014348150103201501032015Copyright ©; 2014, Fedyanin M.Y., Tryakin A.A., Tjulandin S.A.Copyright ©; 2014, Федянин М.Ю., Трякин А.А., Тюляндин С.А.2014Fedyanin M.Y., Tryakin A.A., Tjulandin S.A.Федянин М.Ю., Трякин А.А., Тюляндин С.А.https://creativecommons.org/licenses/by/4.0https://onco-surgery.info/jour/article/view/83

First-line therapy for metastatic colon cancer is most important for a patient. Its median time to progression constitutes the bulk of the patient’s survival. Clearly, it is necessary to choose the most effective combinations of targeted drugs and chemotherapy regimens. The choice of therapy for patients with colon cancer is governed by both the clinical characteristics of the disease and the molecular changes of a tumor. In recent literature, there has been a great deal of evidence for the use of targeted drugs in different clinical situations; the results of comparative trials of different treatment combinations have been published. This all determines the reconsideration of the choice of a treatment regimen in patients with metastatic colon cancer; it is the topic of the present review.

Первая линия терапии метастатического рака толстой кишки (мРТК) является самой важной для пациента. Медиана ее времени до прогрессирования составляет большую часть продолжительности жизни пациента. Естественно, необходимо выбирать наиболее эффективные комбинации таргетных препаратов и химиотерапевтических режимов. Выбор терапии больных раком толстой кишки определяется как клиническими характеристиками заболевания, так и молекулярными изменениями в опухоли. За последний год появилось много данных по применению таргетных препаратов в различных клинических ситуациях, опубликованы результаты сравнительных исследований различных комбинаций лечебных опций. Все это определяет переосмысливание выбора режима лечения больных у больных мРТК, именно этому и посвящен настоящий обзор.

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