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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Surgery and Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Surgery and Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Хирургия и онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="electronic">2949-5857</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">803</article-id><article-id pub-id-type="doi">10.17650/2949-5857-2025-15-2-11-21</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ARTICLE NUMBERS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>СТАТЬЯ НОМЕРА</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">External beam radiation therapy for cell carcinoma of the anal canal: preparation, planning, details of treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Дистанционная лучевая терапия при плоскоклеточном раке анального канала: подготовка, планирование, нюансы лечения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4944-4035</contrib-id><name-alternatives><name xml:lang="en"><surname>Chernykh</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Черных</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9853-215X</contrib-id><name-alternatives><name xml:lang="en"><surname>Uymanov</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Уйманов</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-9587-3794</contrib-id><name-alternatives><name xml:lang="en"><surname>Kurenkov</surname><given-names>D. V.</given-names></name><name xml:lang="ru"><surname>Куренков</surname><given-names>Д. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Dmitry Valeryevich Kurenkov,</bold></p><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p><bold>Дмитрий Валерьевич Куренков,</bold></p><p>115522 Москва, Каширское шоссе, 24</p></bio><email>dokerdk@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3028-7578</contrib-id><name-alternatives><name xml:lang="en"><surname>Ivanov</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Иванов</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-5670-9451</contrib-id><name-alternatives><name xml:lang="en"><surname>Alieva</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Алиева</surname><given-names>Э. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0101-512X</contrib-id><name-alternatives><name xml:lang="en"><surname>Romanova</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Романова</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-8480-7765</contrib-id><name-alternatives><name xml:lang="en"><surname>Zavistovsky</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Завистовский</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-6250-2957</contrib-id><name-alternatives><name xml:lang="en"><surname>Mironova</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Миронова</surname><given-names>О. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-9844-3589</contrib-id><name-alternatives><name xml:lang="en"><surname>Kryilova</surname><given-names>T. A.</given-names></name><name xml:lang="ru"><surname>Крылова</surname><given-names>Т. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-06-19" publication-format="electronic"><day>19</day><month>06</month><year>2025</year></pub-date><volume>15</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>11</fpage><lpage>21</lpage><history><date date-type="received" iso-8601-date="2025-06-17"><day>17</day><month>06</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-06-17"><day>17</day><month>06</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, ABV-press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, АБВ-пресс</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">ABV-press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://onco-surgery.info/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://onco-surgery.info/jour/article/view/803">https://onco-surgery.info/jour/article/view/803</self-uri><abstract xml:lang="en"><p>In the absence of a unified approach in numerous recommendations and consensuses for chemoradiotherapy of patients with squamous cell non-metastatic anal canal cancer, medical practitioners need a practical consolidating “tool” combining all information sources, which is the purpose of this article.</p><p>Based on international recommendations and consensuses on radiation therapy, the expert group analyzed the data and compiled the most optimal approaches to target volume delineation. This was done based on a balanced analysis of the advantages and disadvantages of the fractionation modes used and the criteria for dose distribution in irradiated apparatus proposed by both other authors and the team of the radiotherapy department of the N. N. Blokhin National Medical Research Center of Oncology. Examples of delineating anatomical structures and target volumes are provided.</p></abstract><trans-abstract xml:lang="ru"><p>При отсутствии единства взглядов в многочисленных рекомендациях и консенсусах практикующему врачу необходим суммирующий прикладной «инструмент» по химиолучевой терапии пациентов с плоскоклеточным неметастатическим раком анального канала, объединяющий все вышеперечисленные источники, создание которого и стало целью данной работы.</p><p>На основе международных рекомендаций и консенсусов по лучевой терапии экспертная группа провела анализ данных и компиляцию наиболее оптимальных подходов по оконтуриванию целевых объемов. С этой целью группа оценила преимущества и недостатки используемых режимов фракционирования и критериев дозного распределения в облучаемых тканях. При этом учитывался опыт коллектива отделения радиотерапии Национального медицинского исследовательского центра онкологии им. Н.Н. Блохина и других авторов. Представлены примеры оконтуривания анатомических структур и целевых объемов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>anal cancer</kwd><kwd>chemoradiotherapy</kwd><kwd>pre-radiation preparation</kwd><kwd>standard risk volume</kwd><kwd>planning target volume</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак анального канала</kwd><kwd>химиолучевая терапия</kwd><kwd>предлучевая подготовка</kwd><kwd>объем стандартного риска</kwd><kwd>режим фракционирования</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Gordeev S.S., Besova N.S., Mamedli Z.Z. et al. Practical recommendations for the treatment of anal canal cancer and skin of the perianal area. Practical recommendations RUSSCO. Zlokachestvennye opukholi = Malignant Tumours 2022;12(3s2-1):455–66. (In Russ.). DOI: 10.18027/2224-5057-2022-12-3s2-455-466</mixed-citation><mixed-citation xml:lang="ru">Гордеев С.С., Бесова Н.С., Мамедли З.З. и др. Практические рекомендации по лечению рака анального канала и кожи перианальной области. Практические рекомендации RUSSCO. Злокачественные опухоли 2022;12(3s2-1):455–66. DOI: 10.18027/2224-5057-2022-12-3s2-455-466</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><mixed-citation>Ng M., Leong T., Chander S. et al. Australasian Gastro Intestinal Trials Group (AGITG) contouring atlas and planning guidelines for intensity-modulated radiotherapy in anal cancer. Int J Radiation Oncol Biol Phys 2012;83(5):1455–62. DOI: 10.1016/j.ijrobp.2011.12.058</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Myerson R.J., Garofalo M.C., El Naqa I. et al. Elective clinical target volumes for conformal therapy in anorectal cancer: a radiation therapy oncology group consensus panel contouring atlas. Int J Radiat Oncol Biol Phys 2009;74:824–30. DOI: 10.1016/j.ijrobp.2008.08.070</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Valentini V., Gambacorta M.A., Barbaro B. et al. International consensus guidelines on clinical target volume delineation in rectal cancer. Radiother Oncol 2016;120:195–201. DOI: 10.1016/j.radonc.2016.07.017</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Dapper H., Schiller K., Münch S. et al. Have we achieved adequate recommendations for target volume definitions in anal cancer? A PET imaging-based patterns of failure analysis in the context of established contouring guidelines. BMC Cancer 2019;19(1):742. DOI: 10.1186/s12885-019-5970-0</mixed-citation></ref></ref-list></back></article>
