Surgery and Oncology

Хирургия и онкология

2949-5857

Publishing House ABV Press

10.17650/2220-3478-2013-0-2-48-51

CASE REPORT

КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ

CLINICAL EXPERIENCE OF COMBINED AVASTIN THERAPY IN METASTATIC COLORECTAL CANCER

ОПЫТ ПРИМЕНЕНИЯ АВАСТИНА В КОМБИНИРОВАННОМ ЛЕЧЕНИИ ПАЦИЕНТА С ДИССЕМИНИРОВАННЫМ РАКОМ ТОЛСТОЙ КИШКИ

Ekimov

V. A.

Екимов

В. А.

Russian Federation

vladekimov@gmail.com

City Clinical Hospital № 1, Korolev, Moscow regionМБУЗ «Городская больница № 1», Королев, Московская область

27062013

48512802201528022015

2013

Ekimov V.A.

Екимов В.А.

https://creativecommons.org/licenses/by/4.0

https://onco-surgery.info/jour/article/view/74

Treatment of patients with metastatic colorectal cancer (mCRC) is one of the priority questions in oncology. Despite the significant progress in chemotherapy treatment, development of target agents is the only way of further improvement of the results. Bevacizumab (Avastin) is the first biologic demonstrated it’s efficacy in 1st and 2nd therapy lines in mCRC patients and what’s more important – in continuation with first two serial chemotherapy lines.

Author presents his own experience of prolonged bevacizumab (Avastin) therapy in several serial therapy lines in mCRC patient.

Лечение больных метастатическим колоректальным раком (мКРР) относится к числу приоритетных вопросов онкологии. Несмотря на значительный прогресс в химиотерапии, дальнейшее улучшение результатов лечения связано с развитием таргетных препаратов. Первым препаратом, продемонстрировавшим свою эффективность в 1-й и 2-й линиях терапии, а также на протяжении последовательных первых двух линий терапии, является бевацизумаб (Авастин).

Автор приводит собственный опыт эффективного длительного применения бевацизумаба (Авастина) в нескольких последовательных линиях терапии у больного мКРР.

metastatic colorectal cancerbevacizumab

метастатический колоректальный ракбевацизумаб

1. Состояние онкологической помощи населению России в 2011 году. Под ред. В.И. Чиссова, В.В. Старинского, Г.В. Петровой. М.: ФГУ «МНИОИ им. П.А. Герцена» Минздравсоцразвития России, 2012. 260 с.

Состояние онкологической помощи населению России в 2011 году. Под ред. В.И. Чиссова, В.В. Старинского, Г.В. Петровой. М.: ФГУ «МНИОИ им. П.А. Герцена» Минздравсоцразвития России, 2012. 260 с.

2. Rosen O., Yi J., Hurwitz H.I. et al. Clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Ann Oncol 2008;19 (Suppl. 6):vi 19, abstr 0–035.

Rosen O., Yi J., Hurwitz H.I. et al. Clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Ann Oncol 2008;19 (Suppl. 6):vi 19, abstr 0–035.

3. Hurwitz H.I., Yi J., Ince W. et al. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist 2009 Jan;14(1):22–8.

Hurwitz H.I., Yi J., Ince W. et al. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist 2009 Jan;14(1):22–8.

4. Hurwitz H., Fehrenbacher L., Novotny W. et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335–42.

Hurwitz H., Fehrenbacher L., Novotny W. et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335–42.

5. Saltz L.B., Clarke S., Diaz-Rubio E. et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer:a randomized phase III study. J Clin Oncol 2008;26:2013–9.

Saltz L.B., Clarke S., Diaz-Rubio E. et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer:a randomized phase III study. J Clin Oncol 2008;26:2013–9.

6. Giantonio B.J., Catalano P.J., Meropol N.J. et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007;25:1539–44.

Giantonio B.J., Catalano P.J., Meropol N.J. et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007;25:1539–44.

7. Diaz-Rubio E., Gomez-Espana A., Massuti B. et al. First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: the phase III MACRO TTD study. Oncologist 2012;17(1):15–25.

Diaz-Rubio E., Gomez-Espana A., Massuti B. et al. First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: the phase III MACRO TTD study. Oncologist 2012;17(1):15–25.

8. Van Cutsem E., Rivera F., Berry S. et al. Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol 2009;20(11):1842–7.

Van Cutsem E., Rivera F., Berry S. et al. Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol 2009;20(11):1842–7.

9. Bendell J.C., Bekaii-Saab T.S., Cohn A.L. et al. Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-bevacizumab or FOLFIRI-bevacizumab: results from ARIES,a bevacizumab observational cohort study. Oncologist 2012 Sep 26;17(12):1486–95 [Epub ahead of print].

Bendell J.C., Bekaii-Saab T.S., Cohn A.L. et al. Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-bevacizumab or FOLFIRI-bevacizumab: results from ARIES,a bevacizumab observational cohort study. Oncologist 2012 Sep 26;17(12):1486–95 [Epub ahead of print].

10.

10. Kozloff M., Yood M.U., Berlin J. et al. Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: the BRiTE observational cohort study. Oncologist 2009;14:862–70.

Kozloff M., Yood M.U., Berlin J. et al. Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: the BRiTE observational cohort study. Oncologist 2009;14:862–70.

11.

11. Arnold D., Andre T., Bennouna J. et al. Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: results of randomized phase III intergroup study. J Clin Oncol 2012;30(Suppl. 15): abstr. CRA 3503.

Arnold D., Andre T., Bennouna J. et al. Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: results of randomized phase III intergroup study. J Clin Oncol 2012;30(Suppl. 15): abstr. CRA 3503.

12.

12. Bennouna J., Sastre J., Arnold D. et al. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomized phase 3 trial Published Online. Lancet Oncol 2013;14(1):29–37.

Bennouna J., Sastre J., Arnold D. et al. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomized phase 3 trial Published Online. Lancet Oncol 2013;14(1):29–37.

13.

13. Nordlinger B., Van Cutsem E., Gruenberger T. et al. Combination of surgery and chemotherapy and the role of targeted agents in the treatment of patients with colorectal liver metastases: recommendations from an expert panel. Ann Oncol 2009;20:985–92.

Nordlinger B., Van Cutsem E., Gruenberger T. et al. Combination of surgery and chemotherapy and the role of targeted agents in the treatment of patients with colorectal liver metastases: recommendations from an expert panel. Ann Oncol 2009;20:985–92.