Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press57110.17650/2686-9594-2022-12-4-41-51LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫCabozantinib in hepatocellular cancer: from preclinical experiments to observational studiesКабозантиниб при гепатоцеллюлярном раке: от предклинических экспериментов к наблюдательным исследованиямhttps://orcid.org/0000-0001-5615-7806FedyaninM. Yu.ФедянинМ. Ю.
Russian Federation

 Mikhail Yuryevich Fedyanin

115478, Moscow, Kashirskoe Shosse, 24108814, Moscow, Sosenskiy Stan St., 8105203, Moscow, Nizhnyaya Pervomayskaya St., 70

 Михаил Юрьевич Федянин

115478 Москва, Каширское шоссе, 24108814 Москва, ул. Сосенский стан, 8105203 Москва, ул. Нижняя Первомайская, 70

fedianinmu@mail.ruN.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииMoscow Multidisciplinary Clinical Center "Kommunarka", Department of Health of MoscowГБУЗ «Московский многопрофильный клинический центр «Коммунарка» Департамента здравоохранения г. Москвы»National Medical and Surgical Center named after N.I. Pirogov, Ministry of Health of RussiaФГБУ «Национальный медико-хирургический центр им. Н.И. Пирогова» Минздрава России2012202212441512012202220122022Copyright ©; 2022, Fedyanin M.Y.Copyright ©; 2022, Федянин М.Ю.2022Fedyanin M.Y.Федянин М.Ю.https://creativecommons.org/licenses/by/4.0https://onco-surgery.info/jour/article/view/571

Based on the results of registration studies, the drug cabozantinib, the mechanism of action of which is determined by the inhibition of tyrosine kinases on a relatively wide range of cellular receptors, is registered in the treatment of hepatocellular cancer, kidney cancer and thyroid cancer. This literature review collects data on the mechanism of action, the results of preclinical experiments and phases I–III studies. Emphasis is placed on the tolerability and efficacy of the drug in the population of hepatocellular cancer patients.

По результатам регистрационных исследований препарат кабозантиниб, механизм действия которого определяется ингибированием тирозинкиназ относительно широкого спектра клеточных рецепторов, зарегистрирован в лечении гепатоцеллюлярного рака, рака почки и рака щитовидной железы. В данном обзоре литературы собраны данные по механизму действия, результаты предклинических экспериментов и исследований I–III фаз. Акцент сделан на особенностях переносимости и эффективности препарата в популяции пациентов с гепатоцеллюлярным раком.

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