Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press50910.17650/2686-9594-2021-11-2-44-48LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫBiochemical markers of ovarian stromal cell tumorsБиохимические маркеры в диагностике стромально-клеточных опухолей яичникаhttps://orcid.org/0000-0003-4915-2219BeishembaevA. M.БейшембаевА. М.
Kyrgyzstan

Almaz Mukashevich Beishembaev

144а Bokonbaeva St., Bishkek 720064

Алмаз Мукашевич Бейшембаев

720064 Бишкек, ул. Боконбаева, 144а

almazyaka@yandex.comKyrgyz State Medical Institute of Advanced Training and Retraining named after S. B. Daniyarov, Ministry of Health of Kyrgyz RepublicКыргызский государственный медицинский институт переподготовки и повышения квалификации им. С. Б. Даниярова Министерства здравоохранения Кыргызской Республики2811202111244482811202128112021Copyright ©; 2021, Beishembaev A.M.Copyright ©; 2021, Бейшембаев А.М.2021Beishembaev A.M.Бейшембаев А.М.https://creativecommons.org/licenses/by/4.0https://onco-surgery.info/jour/article/view/509

Ovarian stromal cell tumors are a rare group of neoplasms that characterized by an ambiguous prognosis and biological activity associated with the hypersecretion of a number of substances. The review presents the latest data on the biochemical diagnosis of tumors of the stroma of sex cord, including granulosa cell tumor of the ovary. The importance of hormones, 

Стромально-клеточные опухоли яичника являются редкой группой новообразований, для которых характерен неоднозначный прогноз, а также выраженная биологическая активность, связанная с гиперсекрецией ряда соединений. В обзоре переставлены последние данные по биохимической диагностике опухолей стромы полового тяжа, включая гранулезо-клеточную опухоль яичника. Описано значение гормонов, кл

stromal cell ovarian tumorsbiochemical markersстромально-клеточные опухоли яичникабиохимические маркерыBryk S., Farkkila A., Bützow R. et al. Clinical characteristics and survival of patients with an adult-type ovarian granulosa cell tumor: a 56-year singlecenter experience. Int J Gynecol Cancer 2015;25(1):33–41. DOI: 10.1097/IGC.0000000000000304.Kozachenko V.P. Tumors of the genital stroma. Onkoginekologiya = Oncogynecology 2015;(4):41–7. (In Russ.).Козаченко В.П. Опухоли стромы полового тяжа. Онкогинекология 2015;(4):41–7.Schneider D.T., Orbach D., Cecchetto G. et al. Ovarian Sertoli–Leydig cell tumours in children and adolescents: an analysis of the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT). Eur J Cancer 2015;51(4):543–50. DOI: 10.1016/j.ejca.2014.11.013.Seagle B.L., Ann P., Butler S., Shahabi S. Ovarian granulosa cell tumor: A National Cancer Database study. Gynecol Oncol 2017;146(2):285–91. DOI: 10.1016/j.ygyno.2017.05.020.Levin G., Zigron R., Haj-Yahya R. et al. Granulosa cell tumor of ovary: A systematic review of recent evidence. Eur J Obstet Gynecol Reprod Biol 2018;225:57–61. DOI: 10.1016/j.ejogrb.2018.04.002.Färkkilä A., Haltia U.M., Tapper J. et al. Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary. Ann Med 2017;49(5):435–47. DOI: 10.1080/07853890.2017.1294760.Zhordania K.I., Kerzhkovskaya N.S., Payanidi Yu.G. et al. Granulosa cell tumors of the ovary. Diagnostics and treatment. Onkoginekologiya = Oncogynecology 2014;(2):33–41. (In Russ.).Жорданиа К.И., Кержковская Н.С., Паяниди Ю.Г. и др. Гранулезоклеточные опухоли яичника. Диагностика и лечение. Онкогинекология 2014;(2):33–41.Haltia U.M., Hallamaa M., Tapper J. et al. Roles of human epididymis protein 4, carbohydrate antigen 125, inhibin B and anti-Müllerian hormone in the differential diagnosis and follow-up of ovarian granulosa cell tumors. Gynecol Oncol 2017;144(1):83–9. DOI: 10.1016/j.ygyno.2016.11.018.Fux-Otta C., Szafryk de Mereshian P., López de Corominas M. et al. Hyperandrogenism produced by ovarian tumors in women at different life stages. Rev Fac Cien Med Univ Nac Cordob 2014;71(2):122–6.Jashnani K.D., Hegde C.V., Munot S.P. Alfa-fetoprotein secreting ovarian sex cord-stromal tumor. Indian J Pathol Microbiol 2013;56(1):54–6. DOI: 10.4103/0377-4929.116152.Horta M., Cunha T.M., Marques R.C., Felix A. Ovarian Sertoli–Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review. J Radiol Case Rep 2014;8(11):30–41. DOI: 10.3941/jrcr.v8i11.2272.Donovan L.E., Brain P.H., Duggan M.A. Isolated luteinizing hormone (LH) elevation in a woman with secondary amenorrhea: a clue to the diagnosis of an inhibin B-producing thecoma and insights into the influence of inhibin B on LH. Fertil Steril 2010;94(3):1097. DOI: 10.1016/j.fertnstert.2010.02.016.Ran S., Yu Q., Deng S., Xu L. Luteinizing hormone elevation in ovarian granulosa cell tumor: a case report and review of the literature. J Ovarian Res. 2017;10(1):30. DOI: 10.1186/s13048-017-0327-2. PMID: 28438188; PMCID: PMC5404692.Li J., Bao R., Peng S., Zhang C. The molecular mechanism of ovarian granulosa cell tumors. J Ovarian Res 2018;11(1):13. DOI: 10.1186/s13048-018-0384-1.Lim D., Oliva E. Ovarian sex cord-stromal tumours: an update in recent molecular advances. Pathology 2018;50(2):178–89. DOI: 10.1016/j.pathol.2017.10.008.Gadducci A., Cosio S., Carpi A. et al. Serum tumor markers in the management of ovarian, endometrial and cervical cancer. Biomed Pharmacother 2004;58(1):24–38. DOI: 10.1016/j.biopha.2003.11.003.Geerts I., Vergote I., Neven P. et al. The role of inhibins B and antimüllerian hormone for diagnosis and follow-up of granulosa cell tumors. Int J Gynecol Cancer 2009;19(5):847–55. DOI: 10.1111/IGC.0b013e3181a702d1.Mom C.H., Engelen M.J., Willemse P.H. Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center. Gynecol Oncol 2007;105:365–72. DOI: 10.1016/j.ygyno.2006.12.034.Portuesi R., Loppini A., Mancari R. et al. Role of inhibin B in detecting recurrence of granulosa cell tumors of the ovary in postmenopausal patients. Int J Gynecol Cancer 2021;31(6):893–8. DOI: 10.1136/ijgc-2020-002205.Kurihara S., Hirakawa T., Amada S. et al. Inhibin-producing ovarian granulosa cell tumor as a cause of secondary amenorrhea: case report and review of the literature. J Obstet Gynaecol Res 2004;30(6):439–43. DOI: 10.1111/j.1447-0756.2004.00231.x.Beishembaev A.M., Lyubimova N.V., Kushlinsky D.N. Ovarian granulosa cell tumors and inhibin B. Byulleten ekspertnoy biologicheskoy mediciny = Bulletin of Expert Biological Medicine 2010;150(11):567–70. (In Russ.).Бейшембаев А.М., Любимова Н.В., Кушлинский Д.Н. и др. Гранулезоклеточные опухоли яичников и ингибин В. Бюллетень экспертной биологической медицины 2010;150(11):567–70.Singh S.A., Dahshan B., Krc R. et al. Radiographic and Tumor Biomarker Response to Radiotherapy for Recurrent Granulosa Cell Tumor of the Ovary. Cureus 2021;13(2):e13154. DOI: 10.7759/cureus.13154.Lyubimova N.V., Beishembaev A.M., Timofeev Yu.S., Kushlinskiy N.E. Inhibin B in ovarian stromal cell tumors. Uspekhi molekulyarnoy onkologii = Advances in Molecular Oncology 2020;7(1):32–7. (In Russ.). DOI: 10.17650/2313-805X-2020-7-1-32-37.Любимова Н.В., Бейшембаев А.М., Тимофеев Ю.С., Кушлинский Н.Е. Ингибин В при стромально-клеточных опухолях яичников. Успехи молекулярной онкологии 2020;7(1):32–7. DOI: 10.17650/2313-805X-2020-7-1-32-37.Weintraub A., Eldar-Geva T. AntiMullerian hormone (AMH) determinations in the pediatric and adolescent endocrine practice. Pediatr Endocrinol Rev 2017;14(4):364–70. DOI: 10.17458/per.vol14.2017.WG.Mullerian.Chen S., Yang B., Fan J. Diagnostic value of anti-Müllerian hormone in ovarian granulosa cell tumor: A meta-analysis. Eur J Obstet Gynecol Reprod Biol 2020;253:266–72. DOI: 10.1016/j.ejogrb.2020.08.011.Shrikhande L., Shrikhande B., Shrikhande A. AMH and its clinical implications. J Obstet Gynaecol India 2020;70(5):337–41. DOI: 10.1007/s13224-020-01362-0.Chang H.L., Pahlavan N., Halpern E.F., MacLaughlin D.T. Serum Müllerian Inhibiting Substance/anti-Müllerian hormone levels in patients with adult granulosa cell tumors directly correlate with aggregate tumor mass as determined by pathology or radiology. Gynecol Oncol 2009;114(1):57–60. DOI: 10.1016/j.ygyno.2009.02.023.Victoria M., Labrosse J., Krief F. et al. Anti Müllerian hormone: More than a biomarker of female reproductive function. J Gynecol Obstet Hum Reprod 2019;48(1):19–24. DOI: 10.1016/j.jogoh.2018.10.015.