Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press48710.17650/2686-9594-2020-10-3-4-73-83LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫNovel approaches to treatment of locally advanced rectal cancerСовременные подходы к лечению местно-распространенного рака прямой кишкиhttps://orcid.org/0000-0001-5530-3234KachmazovA. A.КачмазовА. А.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 3

andrewkachmazov@gmail.comhttps://orcid.org/0000-0003-4879-2687BolotinaL. V.БолотинаЛ. В.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 3

https://orcid.org/0000-0003-0092-0459KornietskayaA. L.КорниецкаяА. Л.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 3

https://orcid.org/0000-0003-3196-1368KaragodinaYu. B.КарагодинаЮ. Б.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 3

DroshnevaI. V.ДрошневаИ. В.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 3

FedenkoA. A.ФеденкоА. А.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 3

P. A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Center of Radiology, Ministry of Health of RussiaМосковский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России30122020103-473833012202030122020Copyright ©; 2020, ABV-pressCopyright ©; 2020, АБВ-пресс2020ABV-pressАБВ-прессhttps://onco-surgery.info/jour/about/editorialPolicieshttps://onco-surgery.info/jour/article/view/487

Combination of neoadjuvant chemoradiotherapy with subsequent total mesorectum excision and 6-months of adjuvant chemotherapy remains a standard approach to treatment of locally advanced rectal cancer (T3 or T4 and / or N1–3; M0) for more than 15 years, which is reflected in practical guidelines of most leading oncological societies. However, recent data suggests possibilities of more individualized treatment conceptions with a potential of further improvement of long-term therapy outcomes and patient’s quality of life. In this paper we present review of results of clinical trials which investigated new approaches to treatment of locally advanced rectal cancer.

Проведение неоадъювантной химиолучевой терапии с последующим выполнением тотальной мезоректумэктомии и адъювантной химиотерапией в течение 6 мес является стандартным алгоритмом лечения местно-распространенного рака прямой кишки (T3 или T4, и / или N1–2; M0) и в течение более 15 лет входит в практические рекомендации всех ведущих онкологических сообществ. Результаты опубликованных клинических исследований, посвященных изучению данной тематики, свидетельствуют о возможности использования более персонализированных терапевтических подходов, потенциально приводящих к улучшению отдаленных результатов противоопухолевого лечения и качества жизни пациентов. В этой работе мы представляем обзор имеющихся результатов клинических исследований, посвященных индивидуализации стандартного предоперационного лекарственного лечения и принципиально новым концепциям терапии местно-распространенного рака прямой кишки.

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