Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press3410.17650/2220-3478-2014-0-3-9-16REVIEWОБЗОРЫ ЛИТЕРАТУРЫPROMISES FOR TREATING COLON CANCER PATIENTS WITH BRAF GENE MUTATIONПЕРСПЕКТИВЫ ЛЕЧЕНИЯ БОЛЬНЫХ РАКОМ ТОЛСТОЙ КИШКИ С МУТАЦИЕЙ В ГЕНЕ BRAFFedyaninM. Yu.ФедянинМ. Ю.
Russian Federation
fedianinmu@mail.ruTryakinA. A.ТрякинА. А.
Russian Federation
fedianinmu@mail.ruTjulandinS. A.ТюляндинС. А.
Russian Federation
fedianinmu@mail.ruN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва26092014339162602201526022015Copyright ©; 2014, ABV-pressCopyright ©; 2014, АБВ-пресс2014ABV-pressАБВ-прессhttps://onco-surgery.info/jour/about/editorialPolicieshttps://onco-surgery.info/jour/article/view/34

Colon cancer represents a heterogenous disease group, which differ by cancerogenesis mechanisms, molecular alterations, prognosis and treatment possibilities. In modern clinical practice assessment of KRAS and NRAS genes status is already necessary in order to prescribe anti-EGFR treatment for metastatic disease. A separate poor prognosis group are patients with BRAF mutation. In this review we will focus on biological features of BRAF-mutant colorectal cancer, its epidemiology, clinical features on different stages, treatment choice and promising new treatment possibilities.

Рак толстой кишки (РТК) представляет собой гетерогенную группу опухолей, отличающихся как механизмами канцерогенеза и, следовательно, молекулярными изменениями, так и прогнозом течения болезни и особенностями терапии. К настоящему времени в клинической практике уже необходимо оценивать статус генов KRAS и NRAS для определения возможности назначения анти-EGFR препаратов при метастатическом РТК. Обособленной группой больных с неблагоприятным течением болезни являются пациенты с мутацией в гене BRAF в опухоли. В данном обзоре мы сконцентрируемся на биологических особенностях РТК с мутацией в гене BRAF, эпидемиологии, клинических характеристиках болезни на разных стадиях, выборе терапии и перспективных направлениях лечения данной группы пациентов.

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