Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press23910.17650/2220-3478-2018-8-1-19-27REVIEWОБЗОРЫ ЛИТЕРАТУРЫSome aspects of immunotherapy in colon cancerНекоторые аспекты иммунотерапии при раке толстой кишкиhttps://orcid.org/0000-0001-5615-7806FedyaninM. Yu.ФедянинМ. Ю.
Russian Federation
fedianinmu@mail.ruEl’snukaevaKh. Kh.-M.ЭльснукаеваХ. Х.-М.
Russian Federation
https://orcid.org/0000-0003-2245-214XTryakinA. A.ТрякинА. А.
Russian Federation
https://orcid.org/0000-0001-9807-2229TyulyandinS. A.ТюляндинС. А.
Russian Federation
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России290520188119272905201829052018Copyright ©; 2018, Fedyanin M.Y., El’snukaeva K.K., Tryakin A.A., Tyulyandin S.A.Copyright ©; 2018, Федянин М.Ю., Эльснукаева Х.Х., Трякин А.А., Тюляндин С.А.2018Fedyanin M.Y., El’snukaeva K.K., Tryakin A.A., Tyulyandin S.A.Федянин М.Ю., Эльснукаева Х.Х., Трякин А.А., Тюляндин С.А.https://creativecommons.org/licenses/by/4.0https://onco-surgery.info/jour/article/view/239

Colon cancer is known to be resistant to immunotherapy; however, during the last few years, researchers managed to identify a subgroup of patients that response to anti-PD-1 therapy. This encouraged molecular biologists, immunologists, and clinical oncologists to reconsider the role of immunotherapy for colon cancer. A substantial number of studies devoted to this problem have been published so far, which allowed us to prepare a literature review. This review covers the main trends in immunotherapy of colon cancer, including prognostic value of tumor-infiltrating lymphocytes, efficacy of immune checkpoint inhibitors, bispecific monoclonal antibodies, and antitumor vaccines, as well as transformation of non-inflammatory cancer phenotype into the inflammatory one.

Рак толстой кишки является примером опухоли, резистентной к иммунотерапевтическим подходам, тем не менее за последние несколько лет удалось выделить подгруппу пациентов, отвечающих на применение анти-PD-1-моноклональных антител. Это побудило молекулярных биологов, иммунологов и клинических онкологов вновь вернуться к теме иммунотерапии при данной патологии. К настоящему времени накопилось достаточное число работ, посвященных этой теме, что позволило нам подготовить обзор литературы, целью которого явилось обозначить основные направления иммунологии при раке толстой кишки: оценку прогностической значимости опухоль-инфильтрирующих лимфоцитов, эффективность применения ингибиторов иммунных чек-поинтов, биспецифических моноклональных антител и противоопухолевых вакцин, пути перевода невоспалительного фенотипа опухоли в воспалительный.

 

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