Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press23010.17650/2220-3478-2017-7-4-11-19LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫMICROBIOTA, IMMUNE SYSTEM AND COLORECTAL CANCERМИКРОБИОТА, ИММУННАЯ СИСТЕМА И КОЛОРЕКТАЛЬНЫЙ РАКKharchenkoE. P.ХарченкоЕ. П.
Russian Federation

44 Toreza Prospekt, Saint Petersburg 194223

Евгений Петрович Харченко.

194223 Санкт-Петербург, проспект Тореза, 44

neuro.children@mail.ruSolov’evI. A.СоловьевИ. А.
Russian Federation

6 Akademika Lebedeva St., Saint Petersburg 194044

194044 Санкт-Петербург, ул. Академика Лебедева, 6

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of SciencesФГБУН «Институт эволюционной физиологии и биохимии им. И.М. Сеченова» РАНS.M. Kirov Military Medical Academy, Ministry of Defense of RussiaФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» Минобороны России260220187411192702201827022018Copyright ©; 2018, Kharchenko E.P., Solov’ev I.A.Copyright ©; 2018, Харченко Е.П., Соловьев И.А.2018Kharchenko E.P., Solov’ev I.A.Харченко Е.П., Соловьев И.А.https://creativecommons.org/licenses/by/4.0https://onco-surgery.info/jour/article/view/230

The article briefly considers physiological aspects of the human gut microbiota, associations between dysbiosis and colorectal cancer (CRC), disturbance of immune system in CRC, mechanisms of avoidance of immune surveillance by tumors, genetic instability in CRC, collisions and perspective of immunotherapy of CRC.

В статье кратко рассматриваются физиологические аспекты микробиоты кишечника человека, связь дисбиоза с колоректальным раком (КРР), нарушения иммунной системы при развитии КРР, механизмы избегания опухолью иммунного надзора, варианты генетической нестабильности при КРР, коллизии и перспективы иммунотерапии при КРР.

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