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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Surgery and Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Surgery and Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Хирургия и онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="electronic">2949-5857</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">225</article-id><article-id pub-id-type="doi">10.17650/2220-3478-2017-7-3-35-48</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Localization of the primary tumor of the colon: аre there essential differences?</article-title><trans-title-group xml:lang="ru"><trans-title>Локализация первичной опухоли толстой кишки: есть ли принципиальные отличия?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedyanin</surname><given-names>M. Yu.</given-names></name><name xml:lang="ru"><surname>Федянин</surname><given-names>М. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478 Москва, Каширское шоссе, 23</p></bio><email>fedianinmu@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tryakin</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Трякин</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478 Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tjulandin</surname><given-names>S. A.</given-names></name><name xml:lang="ru"><surname>Тюляндин</surname><given-names>С. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478 Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="ru"></institution></aff><aff><institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation</institution></aff></aff-alternatives><aff id="aff3"><institution></institution></aff><aff id="aff4"><institution>ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России</institution></aff><pub-date date-type="pub" iso-8601-date="2017-12-07" publication-format="electronic"><day>07</day><month>12</month><year>2017</year></pub-date><volume>7</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>35</fpage><lpage>48</lpage><history><date date-type="received" iso-8601-date="2017-12-07"><day>07</day><month>12</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-12-07"><day>07</day><month>12</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Fedyanin M.Y., Tryakin A.A., Tjulandin S.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Федянин М.Ю., Трякин А.А., Тюляндин С.А.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Fedyanin M.Y., Tryakin A.A., Tjulandin S.A.</copyright-holder><copyright-holder xml:lang="ru">Федянин М.Ю., Трякин А.А., Тюляндин С.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://onco-surgery.info/jour/article/view/225">https://onco-surgery.info/jour/article/view/225</self-uri><abstract xml:lang="en"><p>Colon cancer is a heterogenous disease with each subtype having a distinct clinical picture and, consequently, different prognosis. Therefore, the tumors can be classified according to their localization: as emerging from the left or right side of the colon. The proximal and distal colon have different embryogenesis which determines the boundary between the right and left colon at the level of the distal margin of the middle third of the colon. In literature, there’s enough data to consider other differences apart from embryogenesis. Right- and left-side colon tumors differ epidemiologically, clinically and pathomorphologically, molecularly and genetically. This, presumably, explains differences in screening, prevention, and treatment of these tumors. The objective of this review is to analyze differences between colon tumors with different localizations and to determine if such subdivision of colon cancer in clinical practice affects treatment and prevention approaches.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>colon cancer</kwd><kwd>primary tumor localization</kwd><kwd>colon microflora</kwd><kwd>targeted therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак толстой кишки</kwd><kwd>локализация первичной опухоли</kwd><kwd>микрофлора толстой кишки</kwd><kwd>таргетная терапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Benedix F., Schmidt U., Mroczkowski P. et al. Colon carcinoma – classification into right and left sided cancer or according to colonic subside? Analysis of 29,568 patients. Eur J Surg Oncol 2011;37(2):134–9. 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