Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press21810.17650/2220-3478-2017-7-2-43-52REVIEWОБЗОРЫ ЛИТЕРАТУРЫMethods of comprehensive geriatric assessment of older patients with rectal cancerМетоды всесторонней гериатрической оценки больных раком прямой кишки пожилого и старческого возрастаGordeevS. S.ГордеевС. С.
Russian Federation

Surgical Department No. 3 (Proctological)

Отделение хирургическое № 3 (проктологическое)

mali62@mail.ruKovalevaYu. Yu.КовалеваЮ. Ю.
Russian Federation

Surgical Department No. 3 (Proctological)

Отделение хирургическое № 3 (проктологическое)

mali62@mail.ruRasulovA. O.РасуловА. О.
Russian Federation

Surgical Department No. 3 (Proctological)

Отделение хирургическое № 3 (проктологическое)

mali62@mail.ruN.N. Blokhin National Medical Research Oncology Center, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России280920177243522809201728092017Copyright ©; 2017, Gordeev S.S., Kovaleva Y.Y., Rasulov A.O.Copyright ©; 2017, Гордеев С.С., Ковалева Ю.Ю., Расулов А.О.2017Gordeev S.S., Kovaleva Y.Y., Rasulov A.O.Гордеев С.С., Ковалева Ю.Ю., Расулов А.О.https://creativecommons.org/licenses/by/4.0https://onco-surgery.info/jour/article/view/218

The article presents a literature review on application of modern risk predictors of complications and morbidity necessary for selection of oncologically justified treatment methods for older patients with rectal cancer taking into account advancement of the disease and concomitant pathology. Use of modern scales, calculators, and questionnaires for evaluation of functional and physical status of this complex patient category by a multidisciplinary team allows to personalize therapy approach, minimize complications and morbidity after specific treatment. Application of the developed algorithms of assessment of older patients creates satisfactory conditions for their treatment based on oncological adequacy, functionality, and safety.

 

 

В работе представлены данные обзора литературы об использовании современных предикторов риска осложнений и летальности, необходимых для выбора онкологически обоснованного метода лечения больных раком прямой кишки пожилого и старческого возраста, с учетом распространенности заболевания и сопутствующей патологии. Использование современных шкал, калькуляторов и опросников для оценки функционального и физического статуса данной тяжелой категории больных с привлечением мультидисциплинарной команды позволяет индивидуализировать подход к терапии, прогнозировать возможные риски, уменьшить осложнения в процессе и летальность после проведенного специфического лечения. Применение разработанных алгоритмов обследования людей пожилого и старческого возраста создает приемлемые условия для их лечения с учетом онкологической адекватности, функциональности и безопасности.

 

 

rectal cancerolder agegeriatric agecomprehensive geriatric assessmentcomorbidityscalesquestionnairessurgical and combination complex treatmentрак прямой кишкипожилой и старческий возраствсесторонняя гериатрическая оценкакоморбидностьшкалыопросникихирургическоекомбинированное и комплексное лечение1. Audisio R.A., Bozzetti F., Gennari R. et al. The surgical management of elderly cancer patients; recommendations of the SIOG surgical task force. Eur J Cancer 2004;40(7):926–38. DOI: 10.1016/j.ejca.2004.01.016. PMID: 15093567.Audisio R.A., Bozzetti F., Gennari R. et al. The surgical management of elderly cancer patients; recommendations of the SIOG surgical task force. Eur J Cancer 2004;40(7):926–38. DOI: 10.1016/j.ejca.2004.01.016. PMID: 15093567.2. Центральная база статистических данных. Федеральная служба государственной статистики. Ожидаемая продолжительность жизни в Российской Федерации. Доступно по: http://www.gks.ru/dbscripts/cbsd/dbinet.cgi. [Central base of statistical data. Federal state statistics service. Life expectancy in the Russian Federation. Available at: http:// www.gks.ru/dbscripts/cbsd/dbinet.cgi. (In Russ.)].Центральная база статистических данных. Федеральная служба государственной статистики. Ожидаемая продолжительность жизни в Российской Федерации. Доступно по: http://www.gks.ru/dbscripts/cbsd/dbinet.cgi. [Central base of statistical data. Federal state statistics service. Life expectancy in the Russian Federation. Available at: http:// www.gks.ru/dbscripts/cbsd/dbinet.cgi. (In Russ.)].3. Cтатистика злокачественных ново-образований в России и странах СНГ в 2012 г. Под ред. М.И. Давыдова, Е.М. Аксель. М., 2014. С. 44, 52, 53, 63. [Statistics of malignant neoplasms in Russia and CIS countries in 2012. Eds.: M.I. Davydov, E.M. Aksel’. Moscow, 2014. Pp. 44, 52, 53, 63. (In Russ.)].Cтатистика злокачественных ново-образований в России и странах СНГ в 2012 г. Под ред. М.И. Давыдова, Е.М. Аксель. М., 2014. С. 44, 52, 53, 63. [Statistics of malignant neoplasms in Russia and CIS countries in 2012. Eds.: M.I. Davydov, E.M. Aksel’. Moscow, 2014. Pp. 44, 52, 53, 63. (In Russ.)].4. Latkauskas T., Rudinskaitė G., Kurtinai-tis J. et al. The impact of age on postoperative outcomes of colorectal cancer patients undergoing surgical treatment. BMC Cancer 2005;5:153. DOI: 10.1186/1471-2407-5-153. PMID: 16324216.Latkauskas T., Rudinskaitė G., Kurtinai-tis J. et al. The impact of age on postoperative outcomes of colorectal cancer patients undergoing surgical treatment. BMC Cancer 2005;5:153. DOI: 10.1186/1471-2407-5-153. PMID: 16324216.5. Papamichael D., Audisio R., Horiot J.-C. et al. Treatment of the elderly colorectal cancer patient: SIOG expert recommendations. Ann Oncol 2009;20(1):5–16.Papamichael D., Audisio R., Horiot J.-C. et al. Treatment of the elderly colorectal cancer patient: SIOG expert recommendations. Ann Oncol 2009;20(1):5–16.6. Ellis G., Langhorne P. Comprehensive geriatric assessment for older hospital patients. Br Med Bull 2004;71:45–59. DOI: 10.1093/bmb/ldh033. PMID: 15684245.Ellis G., Langhorne P. Comprehensive geriatric assessment for older hospital patients. Br Med Bull 2004;71:45–59. DOI: 10.1093/bmb/ldh033. PMID: 15684245.7. Sanoff H.K., Goldberg R.M. Colorectal cancer treatment in older patients. Gastrointest Cancer Res 2007;1(6): 248–53. PMID: 19262903.Sanoff H.K., Goldberg R.M. Colorectal cancer treatment in older patients. Gastrointest Cancer Res 2007;1(6): 248–53. PMID: 19262903.8. Ramesh H.S., Pope D., Gennari R., Audisio R.A. Optimising surgical management of elderly cancer patients. World J Surg Oncol 2005;3(1):17. DOI: 10.1186/1477-7819-3-17. PMID: 15788092.Ramesh H.S., Pope D., Gennari R., Audisio R.A. Optimising surgical management of elderly cancer patients. World J Surg Oncol 2005;3(1):17. DOI: 10.1186/1477-7819-3-17. PMID: 15788092.9. Sun W. Management and outcome of colorectal cancer in elderly patients. Clin Colorectal Cancer 2003;3(3):172–3. DOI: 10.1016/S1533-0028(11)70085-8. PMID: 14706176.Sun W. Management and outcome of colorectal cancer in elderly patients. Clin Colorectal Cancer 2003;3(3):172–3. DOI: 10.1016/S1533-0028(11)70085-8. PMID: 14706176.10. Kravitz R., Reuben D., Davis J. et al. Geriatric home assessment after hospital discharge. J Am Geriatr Soc 1994;42(12):1229–34. PMID: 7983283.Kravitz R., Reuben D., Davis J. et al. Geriatric home assessment after hospital discharge. J Am Geriatr Soc 1994;42(12):1229–34. PMID: 7983283.11. Fabacher D., Josephson K., Pietruszka F. et al. An in-home preventive assessment program for independent older adults: a randomized controlled trial. J Am Geriatr Soc 1994;42(6):630–8. PMID: 8201149.Fabacher D., Josephson K., Pietruszka F. et al. An in-home preventive assessment program for independent older adults: a randomized controlled trial. J Am Geriatr Soc 1994;42(6):630–8. PMID: 8201149.12. Alessi C.A., Stuck A.E., Aronow H.U. et al. The process of care in preventive in-home comprehensive geriatric assessment. J Am Geriatr Soc 1997;45:1044–50. PMID: 9288009.Alessi C.A., Stuck A.E., Aronow H.U. et al. The process of care in preventive in-home comprehensive geriatric assessment. J Am Geriatr Soc 1997;45:1044–50. PMID: 9288009.13. Silverman M., Musa D., Martin D.C. et al. Evaluation of outpatient geriatric assessment: a randomised multi-site trial. J Am Geriatr Soc 1995;43:733–40. PMID: 7602022.Silverman M., Musa D., Martin D.C. et al. Evaluation of outpatient geriatric assessment: a randomised multi-site trial. J Am Geriatr Soc 1995;43:733–40. PMID: 7602022.14. Passik S.D., Dugan W., McDonald M.V. et al. Oncologists’ recognitionPassik S.D., Dugan W., McDonald M.V. et al. Oncologists’ recognitionof depression in their patients with cancer. J Clin Oncol 1998;16(4):1594–600. DOI: 10.1200/JCO.1998.16.4.1594. PMID: 9552071.15. Sargent D.J., Patiyil S., Yothers G. et al. End points for colon cancer adjuvant trials: observations and recommendations based on individual patient data from 20,898 patients enrolled onto 18 randomized trials from the ACCENT group. J Clin Oncol 2007;25(29):4569–74. DOI: 10.1200/JCO.2006.10.4323. PMID: 17876008.Sargent D.J., Patiyil S., Yothers G. et al. End points for colon cancer adjuvant trials: observations and recommendations based on individual patient data from 20,898 patients enrolled onto 18 randomized trials from the ACCENT group. J Clin Oncol 2007;25(29):4569–74. DOI: 10.1200/JCO.2006.10.4323. PMID: 17876008.16. Benson A.B. 3rd, Venook A.P., Cederquist L. et al. Colon cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr CancBenson A.B. 3rd, Venook A.P., Cederquist L. et al. Colon cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr CancNetw 2017;15(3):370–98. PMID: 28275037.17. Kenisand C., Wildiers H., Wedding U. et al. Practice guideline. Comprehensive Geriatric Assessment (CGA) in oncologi-cal patients. 2011.Kenisand C., Wildiers H., Wedding U. et al. Practice guideline. Comprehensive Geriatric Assessment (CGA) in oncologi-cal patients. 2011.18. Decoster L., Van Puyvelde K., Mohile S. et al. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations. Ann Oncol 2015;26(2):288–300. DOI: 10.1093/annonc/mdu210.Decoster L., Van Puyvelde K., Mohile S. et al. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations. Ann Oncol 2015;26(2):288–300. DOI: 10.1093/annonc/mdu210.19. Burhenn P.S., McCarthy A.L., Begue A. Geriatric assessment in daily oncology practice for nurses and allied health care professionals: Opinion paper of the Nursing and Allied Health Interest Group of the International Society of Geriatric Oncology (SIOG). J Geriatr Oncol 2016;7(5):315–24. DOI: 10.1016/j.jgo.2016.02.006.Burhenn P.S., McCarthy A.L., Begue A. Geriatric assessment in daily oncology practice for nurses and allied health care professionals: Opinion paper of the Nursing and Allied Health Interest Group of the International Society of Geriatric Oncology (SIOG). J Geriatr Oncol 2016;7(5):315–24. DOI: 10.1016/j.jgo.2016.02.006.20. Tan K.Y., Kawamura Y., Mizokami K. et al. Colorectal surgery in octogenarian patients – outcomes and predictors of morbidity. Int J Colorectal Dis 2009;24(2):185–9. DOI: 10.1007/s00384-008-0615-9.Tan K.Y., Kawamura Y., Mizokami K. et al. Colorectal surgery in octogenarian patients – outcomes and predictors of morbidity. Int J Colorectal Dis 2009;24(2):185–9. DOI: 10.1007/s00384-008-0615-9.21. Sandstrom R., Drott C., Hyltander A. et al. The effect of postoperative intravenous feeding (TPN) on outcome following major surgery evaluated in a randomized study. Ann Surg 1993;217(2):185–95. PMID: 8439216.Sandstrom R., Drott C., Hyltander A. et al. The effect of postoperative intravenous feeding (TPN) on outcome following major surgery evaluated in a randomized study. Ann Surg 1993;217(2):185–95. PMID: 8439216.22. Сorreia M.I., Caiaffa W.T., da Silva A.L., Waitzberg D.L. Risk factors for malnutrition in patients undergoing gastroentero-logical and hernia surgery: an analysis of 374 patients. Nutr Hosp 2001;16(2): 59–64. PMID: 11443835.Сorreia M.I., Caiaffa W.T., da Silva A.L., Waitzberg D.L. Risk factors for malnutrition in patients undergoing gastroentero-logical and hernia surgery: an analysis of 374 patients. Nutr Hosp 2001;16(2): 59–64. PMID: 11443835.23. Bozzetti F., Forbes A. The ESPEN clinical practice Guidelines on Parenteral Nutrition: present status and perspectives for future research. Clin Nutr 2009;28(4):359–64. DOI: 10.1016/j.clnu.2009.05.010.Bozzetti F., Forbes A. The ESPEN clinical practice Guidelines on Parenteral Nutrition: present status and perspectives for future research. Clin Nutr 2009;28(4):359–64. DOI: 10.1016/j.clnu.2009.05.010.24. von Meyenfeldt M.F., Meijerink W.J., Roufflart M.M. et al. Perioperative nutritional support: a randomized clinical trial. Clin Nutr 1992;11(4):180–6. PMID: 16839996.von Meyenfeldt M.F., Meijerink W.J., Roufflart M.M. et al. Perioperative nutritional support: a randomized clinical trial. Clin Nutr 1992;11(4):180–6. PMID: 16839996.25. The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group. Perioperative total parenteral nutrition in surgical patients. N Engl J Med 1991;325(8): 525–32. DOI: 10.1056/NEJM199108223250801. PMID: 1906987.The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group. Perioperative total parenteral nutrition in surgical patients. N Engl J Med 1991;325(8): 525–32. DOI: 10.1056/NEJM199108223250801. PMID: 1906987.26. Detsky A.S., Baker J.P., O’Rourke K., Goel V. Perioperative parenteral nutrition: a meta-analysis. Ann Intern Med 1987;107(2):195–203. PMID: 3111322.Detsky A.S., Baker J.P., O’Rourke K., Goel V. Perioperative parenteral nutrition: a meta-analysis. Ann Intern Med 1987;107(2):195–203. PMID: 3111322.27. Bozzetti F., Gavazzi C., Miceli R. et al. Perioperative total parenteral nutritionBozzetti F., Gavazzi C., Miceli R. et al. Perioperative total parenteral nutritionin malnourished gastrointestinal cancer patients: a randomized clinical trial. J Par-enter Enteral Nutr 2000;24(1):7–14. DOI: 10.1177/014860710002400107. PMID: 10638466.28. Waitzberg D.L., Saito H., Plank L.D. et al. Postsurgical infections are reduced with specialized nutrition support. World J Surg 2006;30(8):1592–604. DOI: 10.1007/s00268-005-0657-x. PMID: 16794908.Waitzberg D.L., Saito H., Plank L.D. et al. Postsurgical infections are reduced with specialized nutrition support. World J Surg 2006;30(8):1592–604. DOI: 10.1007/s00268-005-0657-x. PMID: 16794908.29. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Rectal Cancer. Version 2.2017. NCCN Evidence Blokcs. 2017.NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Rectal Cancer. Version 2.2017. NCCN Evidence Blokcs. 2017.30. Давыдов М.И. Онкология. Клинические рекомендации. М., 2015. С. 83. [Davydov M.I. Oncology. Clinical guidelines. Moscow, 2015. P. 83.Давыдов М.И. Онкология. Клинические рекомендации. М., 2015. С. 83. [Davydov M.I. Oncology. Clinical guidelines. Moscow, 2015. P. 83.(In Russ.)].31. Glimelius B., Tiret E., Cervantes A. et al. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013;24(Suppl 6): vi81–8. DOI: 10.1093/annonc/mdt240.Glimelius B., Tiret E., Cervantes A. et al. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013;24(Suppl 6): vi81–8. DOI: 10.1093/annonc/mdt240.32. Kaiser M.J., Bauer J.M., Ramsch C. et al. Validation of the Mini Nutritional Assessment Short-Form (MNA-SF): A practical tool for identification of nutritional status. J Nutr Health Aging 2009;13(9):782–8. PMID: 19812868.Kaiser M.J., Bauer J.M., Ramsch C. et al. Validation of the Mini Nutritional Assessment Short-Form (MNA-SF): A practical tool for identification of nutritional status. J Nutr Health Aging 2009;13(9):782–8. PMID: 19812868.33. Vellas B., Guigoz Y., Garry P.J. et al. The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients. Nutrition 1999;15(2):116–22. PMID: 9990575.Vellas B., Guigoz Y., Garry P.J. et al. The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients. Nutrition 1999;15(2):116–22. PMID: 9990575.34. Nanayakkara C., Lekamwasam S. Validity of the 5-item Barthel Index in the assessment of physical dependence in the elderly. Asian J Gerontol Geriatr 2015;10(2):79–82.Nanayakkara C., Lekamwasam S. Validity of the 5-item Barthel Index in the assessment of physical dependence in the elderly. Asian J Gerontol Geriatr 2015;10(2):79–82.35. Barberger-Gateau P., Commenges D., Gagnon M. et al. Instrumental Activities of Daily Living as a screening tool for cognitive impairment and dementia in elderly community dwellers. J Am Geriatr Soc 1992;40(11):1129–34. PMID: 1401698.Barberger-Gateau P., Commenges D., Gagnon M. et al. Instrumental Activities of Daily Living as a screening tool for cognitive impairment and dementia in elderly community dwellers. J Am Geriatr Soc 1992;40(11):1129–34. PMID: 1401698.36. Dunn J., Lynch B., Rinaldis M. et al. Dimensions of quality of life and psychosocial variables most salient to colorectal cancer patients. Psychooncology 2006;15(1):20–30. DOI: 10.1002/pon.919. PMID: 15929055.Dunn J., Lynch B., Rinaldis M. et al. Dimensions of quality of life and psychosocial variables most salient to colorectal cancer patients. Psychooncology 2006;15(1):20–30. DOI: 10.1002/pon.919. PMID: 15929055.37. Carmack C.L., Basen-Engquist K., Yuan Y. et al. Feasibility of an expressive-disclosure group intervention for post-treatment colorectal cancer patients: results of the Healthy Expressions study. Cancer 2011;117(21):4993–5002. DOI: 10.1002/cncr.26110.Carmack C.L., Basen-Engquist K., Yuan Y. et al. Feasibility of an expressive-disclosure group intervention for post-treatment colorectal cancer patients: results of the Healthy Expressions study. Cancer 2011;117(21):4993–5002. DOI: 10.1002/cncr.26110.38. Graça Pereira M., Figueiredo A.P., Fin-cham F.D. Anxiety, depression, traumatic stress and quality of life in colorectal cancer after different treatments: A study with Portuguese patients and their partners. Eur J Oncol Nurs 2011;16(3):227–32. DOI: 10.1016/j.ejon.2011.06.006.Graça Pereira M., Figueiredo A.P., Fin-cham F.D. Anxiety, depression, traumatic stress and quality of life in colorectal cancer after different treatments: A study with Portuguese patients and their partners. Eur J Oncol Nurs 2011;16(3):227–32. DOI: 10.1016/j.ejon.2011.06.006.39. Potash M., Breibart W. Affective disorders in advanced cancer. Hematol Oncol Clin North Am 2002;16(3):671–700. PMID: 12170575.Potash M., Breibart W. Affective disorders in advanced cancer. Hematol Oncol Clin North Am 2002;16(3):671–700. PMID: 12170575.40. Berardi D., Menchetti M., De Ronchi D. et al. Late-life depression in primary care: A nationwide Italian epidemiological survey. J Am Geriatr Soc 2002;50(1):77–83. PMID: 12028250.Berardi D., Menchetti M., De Ronchi D. et al. Late-life depression in primary care: A nationwide Italian epidemiological survey. J Am Geriatr Soc 2002;50(1):77–83. PMID: 12028250.41. Cassem E.M. Depressive disorders in the medically ill: an overview. Psychosomatics 1995;36(2):S2–10. DOI: 10.1016/S0033-3182(95)71698-X. PMID: 7724710.Cassem E.M. Depressive disorders in the medically ill: an overview. Psychosomatics 1995;36(2):S2–10. DOI: 10.1016/S0033-3182(95)71698-X. PMID: 7724710.42. Schneider G., Kruse A., Nehen H.G. et al. The prevalence and differential diagnosis of subclinical depressive syndromes in inpatients 60 years or older. Psychother Psychosom 2000;69(5):251–60. DOI: 12404. PMID: 10965290.Schneider G., Kruse A., Nehen H.G. et al. The prevalence and differential diagnosis of subclinical depressive syndromes in inpatients 60 years or older. Psychother Psychosom 2000;69(5):251–60. DOI: 12404. PMID: 10965290.43. Vanitallie T.B. Subsyndromal depression in the elderly: underdiagnosed and under-treated. Metabolism 2005;54(5 Suppl 1): 39–44. DOI: 10.1016/j.metabol.2005.01.012. PMID: 15877312.Vanitallie T.B. Subsyndromal depression in the elderly: underdiagnosed and under-treated. Metabolism 2005;54(5 Suppl 1): 39–44. DOI: 10.1016/j.metabol.2005.01.012. PMID: 15877312.44. Lyness J.M., King D.A., Cox C. et al. The importance of subsyndromal depression in older primary care patients: prevalence and associated functional disability. J Am Geriatr Soc 1999;47:757–8. PMID: 10366161.Lyness J.M., King D.A., Cox C. et al. The importance of subsyndromal depression in older primary care patients: prevalence and associated functional disability. J Am Geriatr Soc 1999;47:757–8. PMID: 10366161.45. Jogerst G. J., Zheng S., Vanderlip E. Predictors of Treatments Acceptable to Patients for Late-Life Depression. Scientific-WorldJournal 2013;2013:207493. DOI: 10.1155/2013/207493.Jogerst G. J., Zheng S., Vanderlip E. Predictors of Treatments Acceptable to Patients for Late-Life Depression. Scientific-WorldJournal 2013;2013:207493. DOI: 10.1155/2013/207493.46. Zabora J., Brintzenhofeszoc K., Curbow B. et al. The prevalence of psychological distress by cancer site. Psychooncology 2001;10(1):19–28. PMID: 11180574.Zabora J., Brintzenhofeszoc K., Curbow B. et al. The prevalence of psychological distress by cancer site. Psychooncology 2001;10(1):19–28. PMID: 11180574.47. Miranda D.O., Soares de Lima T.A., Azevedo L.R. et al. Proinflammatory cyto-kines correlate with depression and anxiety in colorectal cancer patients. Bio Med Res Int 2014;2014:739650. DOI: 10.1155/2014/739650.Miranda D.O., Soares de Lima T.A., Azevedo L.R. et al. Proinflammatory cyto-kines correlate with depression and anxiety in colorectal cancer patients. Bio Med Res Int 2014;2014:739650. DOI: 10.1155/2014/739650.48. Yesavage J.A., Brink T.L., Rose T.L. et al. Development and validation of a Geriatric Depression Screening Scale. J Psychiatr Res 1983;17(1):37–49. PMID: 7183759.Yesavage J.A., Brink T.L., Rose T.L. et al. Development and validation of a Geriatric Depression Screening Scale. J Psychiatr Res 1983;17(1):37–49. PMID: 7183759.49. Huppert F.A., Kopelman M.D. Rates of forgetting in normal aging: a comparison with dementia. Neuropsychology 1989;27(6):849–60. PMID: 2755593.Huppert F.A., Kopelman M.D. Rates of forgetting in normal aging: a comparison with dementia. Neuropsychology 1989;27(6):849–60. PMID: 2755593.50. Kopelman M.D. Amnesia: organic and psychogenic. Br J Psych 1987;150:428–42. PMID: 3311268.Kopelman M.D. Amnesia: organic and psychogenic. Br J Psych 1987;150:428–42. PMID: 3311268.51. Дамулин И.В. Болезнь Альцгеймера и сосудистая деменция. Под ред.Дамулин И.В. Болезнь Альцгеймера и сосудистая деменция. Под ред.Н.Н. Яхно. М., 2002. С. 85. [Damulin I.V. Alzheimer’s disease and vascular dementia. Ed. N.N. Yakhno. Moscow, 2002. P. 85. (In Russ.)].52. Larrabee G.J., Crook T.M. 3rd. Estimated prevalence of age associated memory impairment derived from standardized tests of memory function. Int Psychogeriatr 1994;6(1):95–104. PMID: 8054499.Larrabee G.J., Crook T.M. 3rd. Estimated prevalence of age associated memory impairment derived from standardized tests of memory function. Int Psychogeriatr 1994;6(1):95–104. PMID: 8054499.53. Захаров В.В. Когнитивные нарушения в неврологической практике. Трудный пациент 2005;(5):15–8. [Zakharov V.V. Cognitive disorders in neurological practice. Trudnyy patsient = Difficult Patient 2005;(5):15–8. (In Russ.)].Захаров В.В. Когнитивные нарушения в неврологической практике. Трудный пациент 2005;(5):15–8. [Zakharov V.V. Cognitive disorders in neurological practice. Trudnyy patsient = Difficult Patient 2005;(5):15–8. (In Russ.)].54. Alzheimer’s disease: biology, diagnosis and therapeutics. Eds.: K. Iqbal, B. Winblad, T. Nishumura et al. 1997.Alzheimer’s disease: biology, diagnosis and therapeutics. Eds.: K. Iqbal, B. Winblad, T. Nishumura et al. 1997.55. Lovenstone S., Gauthier S. Management of dementia. London: Martin Dunitz, 2001. P. 201.Lovenstone S., Gauthier S. Management of dementia. London: Martin Dunitz, 2001. P. 201.56. Wronski M., Arbit E. Resection of brain metastases from colorectal carcinoma in 73 patients. Cancer 1999;85(8): 1677–85. PMID: 10223560.Wronski M., Arbit E. Resection of brain metastases from colorectal carcinoma in 73 patients. Cancer 1999;85(8): 1677–85. PMID: 10223560.57. Hammoud M.A., McCutcheon I.E., El-souki R. et al. Colorectal carcinoma and brain metastasis: distribution, treatment, and survival. Ann Surg Oncol 1996;3(5):453–63. PMID: 8876887.Hammoud M.A., McCutcheon I.E., El-souki R. et al. Colorectal carcinoma and brain metastasis: distribution, treatment, and survival. Ann Surg Oncol 1996;3(5):453–63. PMID: 8876887.58. Awan S., Shahbaz N., Akhtar S.W. et al. Validation Study of the Mini-Mental State Examination in Urdu Language for Pakistani Population. Open Neurol J 2015;9:53–8. DOI: 10.2174/1874205X01509010053.Awan S., Shahbaz N., Akhtar S.W. et al. Validation Study of the Mini-Mental State Examination in Urdu Language for Pakistani Population. Open Neurol J 2015;9:53–8. DOI: 10.2174/1874205X01509010053.59. Charlson M., Szatrowski T.P., Peterson J., Gold J. Validation of a combined comorbidity index. J Clin Epidemiol 1994;47(11):1245–51.Charlson M., Szatrowski T.P., Peterson J., Gold J. Validation of a combined comorbidity index. J Clin Epidemiol 1994;47(11):1245–51.60. Frenkel W.J., Jongerius E.J., Mandjes-van Uitert M.J. et al. Validation of the Charl-son Comorbidity Index in acutely hospital-ized elderly adults: a prospective cohort study. J Am Geriatr Soc 2014;62(2):342–6. DOI: 10.1111/jgs.12635.Frenkel W.J., Jongerius E.J., Mandjes-van Uitert M.J. et al. Validation of the Charl-son Comorbidity Index in acutely hospital-ized elderly adults: a prospective cohort study. J Am Geriatr Soc 2014;62(2):342–6. DOI: 10.1111/jgs.12635.61. Charlson M.E., Pompei P., Ales K.L., McKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis 1987;40(5):373–83. PMID: 3558716.Charlson M.E., Pompei P., Ales K.L., McKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis 1987;40(5):373–83. PMID: 3558716.62. Teeuwen P.H., Bremers A.J., Groenewoud J.M. et al. Predictive value of POSSUM and ACPGBI scoring in mortality and morbidity of colorectal resection: a case-control study. J Gastroin-test Surg 2011;15(2):294–303. DOI: 10.1007/s11605-010-1354-0.Teeuwen P.H., Bremers A.J., Groenewoud J.M. et al. Predictive value of POSSUM and ACPGBI scoring in mortality and morbidity of colorectal resection: a case-control study. J Gastroin-test Surg 2011;15(2):294–303. DOI: 10.1007/s11605-010-1354-0.63. Brooks M.J., Sutton R., Sarin S. Comparison of Surgical Risk Score, POSSUM and p-POSSUM in higher-risk surgical patients. Br J Surg 2005;92(10):1288–92. DOI: 10.1002/bjs.5058. PMID: 15981213.Brooks M.J., Sutton R., Sarin S. Comparison of Surgical Risk Score, POSSUM and p-POSSUM in higher-risk surgical patients. Br J Surg 2005;92(10):1288–92. DOI: 10.1002/bjs.5058. PMID: 15981213.64. Slim K., Panis Y., Alves A. et al. Predicting postoperative mortality in patients undergoing colorectal surgery. World J Surg 2006;30(1):100–6. DOI: 10.1007/s00268-005-0081-2. PMID: 16369701.Slim K., Panis Y., Alves A. et al. Predicting postoperative mortality in patients undergoing colorectal surgery. World J Surg 2006;30(1):100–6. DOI: 10.1007/s00268-005-0081-2. PMID: 16369701.65. Hurria A., Togawa K., Mohile S.G. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol 2011;29(25):3457–65. DOI: 10.1200/JCO.2011.34.7625.Hurria A., Togawa K., Mohile S.G. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol 2011;29(25):3457–65. DOI: 10.1200/JCO.2011.34.7625.66. Hurria A., Cirrincione C.T., Muss H.B. et al. Implementing a Geriatric Assessment in Cooperative Group Clinical Cancer Trials: CALGB 360401. J Clin Oncol 2011;29(10):1290–6. DOI: 10.1200/JCO.2010.30.6985.Hurria A., Cirrincione C.T., Muss H.B. et al. Implementing a Geriatric Assessment in Cooperative Group Clinical Cancer Trials: CALGB 360401. J Clin Oncol 2011;29(10):1290–6. DOI: 10.1200/JCO.2010.30.6985.