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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Surgery and Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Surgery and Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Хирургия и онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="electronic">2949-5857</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">217</article-id><article-id pub-id-type="doi">10.17650/2220-3478-2017-7-2-36-42</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Pharmacoeconomic-guided choice of systemic chemotherapy in metastatic colorectal cancer patients</article-title><trans-title-group xml:lang="ru"><trans-title>Фармакоэкономические особенности выбора системной терапии больных метастатическим раком толстой кишки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedyanin</surname><given-names>M. Yu.</given-names></name><name xml:lang="ru"><surname>Федянин</surname><given-names>М. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>edianinmu@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tryakin</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Трякин</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>edianinmu@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rogov</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Рогов</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>edianinmu@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ganicheva</surname><given-names>L. M.</given-names></name><name xml:lang="ru"><surname>Ганичева</surname><given-names>Л. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>edianinmu@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Frolov</surname><given-names>M. Yu.</given-names></name><name xml:lang="ru"><surname>Фролов</surname><given-names>М. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>edianinmu@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tyulyandin</surname><given-names>S. A.</given-names></name><name xml:lang="ru"><surname>Тюляндин</surname><given-names>С. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>edianinmu@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin National Medical Research Oncology Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ  «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Volgograd State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Волгоградский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-09-28" publication-format="electronic"><day>28</day><month>09</month><year>2017</year></pub-date><volume>7</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>36</fpage><lpage>42</lpage><history><date date-type="received" iso-8601-date="2017-09-28"><day>28</day><month>09</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-09-28"><day>28</day><month>09</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Fedyanin M.Y., Tryakin A.A., Rogov V.A., Ganicheva L.M., Frolov M.Y., Tyulyandin S.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Федянин М.Ю., Трякин А.А., Рогов В.А., Ганичева Л.М., Фролов М.Ю., Тюляндин С.А.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Fedyanin M.Y., Tryakin A.A., Rogov V.A., Ganicheva L.M., Frolov M.Y., Tyulyandin S.A.</copyright-holder><copyright-holder xml:lang="ru">Федянин М.Ю., Трякин А.А., Рогов В.А., Ганичева Л.М., Фролов М.Ю., Тюляндин С.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://onco-surgery.info/jour/article/view/217">https://onco-surgery.info/jour/article/view/217</self-uri><abstract xml:lang="en"><p> </p><p>Addition of monoclonal antibodies to metastatic colorectal cancer therapy increases both the survival and treatment costs. This raises the question of economic efficacy of these agents. This review focuses on trials with pharmacoeconomical analysis of chemotherapy and targeted therapy of colorectal cancer.</p><p> </p><p> </p><p> </p><p> </p><p/></abstract><trans-abstract xml:lang="ru"><p>Добавление моноклональных антител к режимам химиотерапии в лечении больных метастатическим раком толстой кишки значимо увеличивает не только продолжительность жизни пациентов, но и стоимость лечения. Соответственно, это ставит вопрос о необходимости экономической оценки применения данных агентов. В настоящем обзоре будет проведен анализ результатов исследований, посвященных фармакоэкономической целесообразности применения различных схем химиотерапии и таргетных препаратов в лечении больных метастатическим раком толстой кишки.</p><p> </p><p> </p></trans-abstract><kwd-group xml:lang="en"><kwd>metastatic colorectal cancer</kwd><kwd>monoclonal antibodies</kwd><kwd>chemotherapy</kwd><kwd>pharmacoeconomic analysis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>метастатический колоректальный рак</kwd><kwd>моноклональные антитела</kwd><kwd>химиотерапия</kwd><kwd>фармакоэкономический анализ</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Drummond M.F., Sculpher M.J., Torran -ce G.W. et al. Methods for the economic evaluation of health care programmes. 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