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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Surgery and Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Surgery and Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Хирургия и онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="electronic">2949-5857</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">205</article-id><article-id pub-id-type="doi">10.17650/2220-3478-2017-7-1-69-71</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CASE REPORT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Microsatellite instability of colorectal cancer in childhood (clinical case)</article-title><trans-title-group xml:lang="ru"><trans-title>Микросателлитная нестабильность колоректального рака в детском возрасте (клиническое наблюдение)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Todorov</surname><given-names>S. S.</given-names></name><name xml:lang="ru"><surname>Тодоров</surname><given-names>С. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Morphology Department, 29 Nakhichevanskiy Lane, Rostov-on-Don 344022, Russia</p></bio><bio xml:lang="ru"><p>Морфологический отдел Россия, 344022 Ростов-на-Дону, Нахичеванский пер., 29</p></bio><email>setodorov@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Rostov State Medical University, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-04-10" publication-format="electronic"><day>10</day><month>04</month><year>2017</year></pub-date><volume>7</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>69</fpage><lpage>71</lpage><history><date date-type="received" iso-8601-date="2017-04-10"><day>10</day><month>04</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-04-10"><day>10</day><month>04</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, ABV-press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, АБВ-пресс</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">ABV-press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://onco-surgery.info/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://onco-surgery.info/jour/article/view/205">https://onco-surgery.info/jour/article/view/205</self-uri><abstract xml:lang="en"><p>Immunohistochemical study of colon adenocarcinoma in the child showed microsatellite instability MLH1, MSH2, MSH6, a high level of proliferative activity of Ki-67 and apoptosis imbalance.</p></abstract><trans-abstract xml:lang="ru"><p>Иммуногистохимическое исследование аденокарциномы толстой кишки у ребенка выявило микросателлитную нестабильность белков MLH1, MSH2, MSH6, высокий уровень пролиферативной активности Ki-67 и дисбаланс процессов апоптоза.</p></trans-abstract><kwd-group xml:lang="en"><kwd>children</kwd><kwd>molecular biology</kwd><kwd>immunohistochemistry</kwd><kwd>colorectal cancer</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>микросателлитная нестабильность</kwd><kwd>иммуногистохимия</kwd><kwd>колоректальный рак</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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