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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Surgery and Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Surgery and Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Хирургия и онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="electronic">2949-5857</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">199</article-id><article-id pub-id-type="doi">10.17650/2220-3478-2017-7-1-11-17</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Results of transanal mesorectumectomy in patients with rectal cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Результаты трансанальной мезоректумэктомии при раке прямой кишки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rasulov</surname><given-names>A. O.</given-names></name><name xml:lang="ru"><surname>Расулов</surname><given-names>А. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478 Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dzhumаbaev</surname><given-names>Kh. E.</given-names></name><name xml:lang="ru"><surname>Джумабаев</surname><given-names>Х. Э.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478 Москва, Каширское шоссе, 23</p></bio><email>millennium88@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kulushev</surname><given-names>V. M.</given-names></name><name xml:lang="ru"><surname>Кулушев</surname><given-names>В. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478 Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mamedli</surname><given-names>Z. Z.</given-names></name><name xml:lang="ru"><surname>Мамедли</surname><given-names>З. З.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478 Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kozlov</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Козлов</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478 Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gordeev</surname><given-names>S. S.</given-names></name><name xml:lang="ru"><surname>Гордеев</surname><given-names>С. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478 Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Baychorov</surname><given-names>A. B.</given-names></name><name xml:lang="ru"><surname>Байчоров</surname><given-names>А. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow 115478, Russia</p></bio><bio xml:lang="ru"><p>Россия, 115478 Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-04-10" publication-format="electronic"><day>10</day><month>04</month><year>2017</year></pub-date><volume>7</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>11</fpage><lpage>17</lpage><history><date date-type="received" iso-8601-date="2017-04-10"><day>10</day><month>04</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-04-10"><day>10</day><month>04</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, ABV-press</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, АБВ-пресс</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">ABV-press</copyright-holder><copyright-holder xml:lang="ru">АБВ-пресс</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://onco-surgery.info/jour/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://onco-surgery.info/jour/article/view/199">https://onco-surgery.info/jour/article/view/199</self-uri><abstract xml:lang="en"><p><bold>Objective</bold>: comparative analysis of specific perioperative features and pathological characteristics of the removed sample after laparoscopic total mesorectumectomy (Lap-TME) and transanal total mesorectumectomy (Ta-TME).<bold>Materials and methods</bold>. A prospective non-randomized controlled study was carried out from November 2013 until September 2016. Patients with сТ1–4aN0–2M0 cancer of low- or medium-ampullar section of rectum were enrolled.<bold>Results</bold>. 55 and 54 patients were included in the Ta-TME and Lap-TME groups respectively. Duration of surgery was 285 min (Ta-TME group) and 260 min (Lap-TME group); median volume of blood loss was less than 100 ml; duration of hospital stay after surgery was 7 days in both groups. 1 (1.8 %) patient from Ta-TME group and 3 (5.6 %) patients from the control group had conversion to open surgery (р = 0.223). Transanal removal of the sample was done in 53.7 % of the cases in Ta-TME group and 25.5 % of the cases in Lap-TME group (p = 0.008). Complications were registered in 27,3 and 24,1 % of the patients respectively (р = 0,436). 90.9 % of the patients from Ta-TME group had Grade 2–3 quality of mesorectumectomy, while in Lap-TME group this parameter was 85.2 % (p = 0.266). Circumferential resection margin damage was observed in 7.3 % of cases from Ta-TME group and 9.3 % of cases from Lap-TME group (p = 0.488).<bold>Conclusion</bold>. Ta-TME does not worsen short-term oncological results. Further randomized studies are required to identify those patients who would benefit from bottoms up mesorectumectomy.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>rectal cancer</kwd><kwd>transanal mesorectumectomy</kwd><kwd>laparoscopic surgery</kwd><kwd>transanal removal of the sample</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак прямой кишки</kwd><kwd>трансанальная мезоректумэктомия</kwd><kwd>лапароскопическая хирургия</kwd><kwd>трансанальное извлечение препарата</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65(1):5–29. DOI: 10.3322/caac.21254.</mixed-citation><mixed-citation xml:lang="ru">Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65(1):5–29. DOI: 10.3322/caac.21254.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Heald R.J., Husband E.M., Ryall R.D. The mesorectum in rectal cancer surgery – the clue to pelvic recurrence? Br J Surg 1982;69(10):613–6. 3. Heald R.J., Ryall R.D. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1986;327(8496):1479–82. PMID: 2425199.</mixed-citation><mixed-citation xml:lang="ru">Heald R.J., Husband E.M., Ryall R.D. The mesorectum in rectal cancer surgery – the clue to pelvic recurrence? Br J Surg 1982;69(10):613–6. 3. Heald R.J., Ryall R.D. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1986;327(8496):1479–82. PMID: 2425199.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">4. Wibe A., Carlsen E., Dahl O. et al. Nationwide quality assurance of rectal cancer treatment. Colorectal Dis 2006;8(3):224–9. DOI: 10.1111/j.1463-1318.2005.00924.x. PMID: 16466564.</mixed-citation><mixed-citation xml:lang="ru">Wibe A., Carlsen E., Dahl O. et al. Nationwide quality assurance of rectal cancer treatment. Colorectal Dis 2006;8(3):224–9. DOI: 10.1111/j.1463-1318.2005.00924.x. PMID: 16466564.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">5. Guillou P.J., Quirke P., Thorpe H. et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 2005;365:1718–26. DOI: 10.1016/S0140-6736(05)66545-2. PMID: 15894098.</mixed-citation><mixed-citation xml:lang="ru">Guillou P.J., Quirke P., Thorpe H. et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet 2005;365:1718–26. DOI: 10.1016/S0140-6736(05)66545-2. PMID: 15894098.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">6. van der Pas M., Deijen C.L., Abis G.S. et al. Conversions in laparoscopic surgery for rectal cancer. Surg Endosc 2016 Oct 20. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="ru">van der Pas M., Deijen C.L., Abis G.S. et al. Conversions in laparoscopic surgery for rectal cancer. Surg Endosc 2016 Oct 20. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">7. Targarona E.M., Balague C., Pernas J.C. et al. Can we predict immediate outcome after laparoscopic rectal surgery? Multivariate analysis of clinical, anatomic, and pathologic features after 3-dimensional reconstruction of the pelvic anatomy. Ann Surg 2008;247(4):642–9. DOI: 10.1097/SLA.0b013e3181612c6a.</mixed-citation><mixed-citation xml:lang="ru">Targarona E.M., Balague C., Pernas J.C. et al. Can we predict immediate outcome after laparoscopic rectal surgery? Multivariate analysis of clinical, anatomic, and pathologic features after 3-dimensional reconstruction of the pelvic anatomy. Ann Surg 2008;247(4):642–9. DOI: 10.1097/SLA.0b013e3181612c6a.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">8. Xu W., Xu Z., Cheng H. et al. Comparison of short-term clinical outcomes between transanal and laparoscopic total mesorectal excision for the treatment of mid and low rectal cancer: A metaanalysis. Eur J Surg Oncol 2016;42(12):1841–50. DOI: 10.1016/j.ejso.2016.09.002.</mixed-citation><mixed-citation xml:lang="ru">Xu W., Xu Z., Cheng H. et al. Comparison of short-term clinical outcomes between transanal and laparoscopic total mesorectal excision for the treatment of mid and low rectal cancer: A metaanalysis. Eur J Surg Oncol 2016;42(12):1841–50. DOI: 10.1016/j.ejso.2016.09.002.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">9. Martínez-Pérez A., de’Angelis N., Brunetti F. A meta-analysis comparing transanal vs. laparoscopic total mesorectal excision for rectal cancer. Eur J Surg Oncol 2016;pii: S0748-7983(16)30970-2. [Epub ahead of print]. DOI: 10.1016/j.ejso.2016.10.030.</mixed-citation><mixed-citation xml:lang="ru">Martínez-Pérez A., de’Angelis N., Brunetti F. A meta-analysis comparing transanal vs. laparoscopic total mesorectal excision for rectal cancer. Eur J Surg Oncol 2016;pii: S0748-7983(16)30970-2. [Epub ahead of print]. DOI: 10.1016/j.ejso.2016.10.030.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">10. Bjørn M.X., Perdawood S.K. Transanal total mesorectal excision – a systematic review. Dan Med J 2015;62(7):pii: A5105. PMID: 26183050.</mixed-citation><mixed-citation xml:lang="ru">Bjørn M.X., Perdawood S.K. Transanal total mesorectal excision – a systematic review. Dan Med J 2015;62(7):pii: A5105. PMID: 26183050.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">11. Deijen C.L., Tsai A., Koedam T.W. et al. Clinical outcomes and case volume effect of transanal total mesorectal excision for rectal cancer: a systematic review. Tech Coloproctol 2016;20(12):811–24. DOI: 10.1007/s10151-016-1545-0. PMID: 2785397.</mixed-citation><mixed-citation xml:lang="ru">Deijen C.L., Tsai A., Koedam T.W. et al. Clinical outcomes and case volume effect of transanal total mesorectal excision for rectal cancer: a systematic review. Tech Coloproctol 2016;20(12):811–24. DOI: 10.1007/s10151-016-1545-0. PMID: 2785397.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">12. van der Pas M.H., Haglind E., Cuesta M.A. et al. Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol 2013;14 (3):210–8. DOI: 10.1016/S1470-2045(13)70016-0.</mixed-citation><mixed-citation xml:lang="ru">van der Pas M.H., Haglind E., Cuesta M.A. et al. Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol 2013;14 (3):210–8. DOI: 10.1016/S1470-2045(13)70016-0.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">13. Fleshman J., Branda M., Sargent D.J. et al. Effect of laparoscopic-assisted resection vs open resection of stage II or III rectal cancer on pathologic outcomes: the ACOSOG Z6051 randomized clinical trial. JAMA 2015;314(13):1346–55. DOI: 10.1001/jama.2015.10529.</mixed-citation><mixed-citation xml:lang="ru">Fleshman J., Branda M., Sargent D.J. et al. Effect of laparoscopic-assisted resection vs open resection of stage II or III rectal cancer on pathologic outcomes: the ACOSOG Z6051 randomized clinical trial. JAMA 2015;314(13):1346–55. DOI: 10.1001/jama.2015.10529.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">14. Stevenson A.R., Solomon M.J., Lumley J.W. et al. Effect of laparoscopicassisted resection vs open resection on pathological outcomes in rectal cancer: the ALaCaRT randomized clinical trial. JAMA 2015;314(13):1356–63. DOI: 10.1001/jama.2015.12009.</mixed-citation><mixed-citation xml:lang="ru">Stevenson A.R., Solomon M.J., Lumley J.W. et al. Effect of laparoscopicassisted resection vs open resection on pathological outcomes in rectal cancer: the ALaCaRT randomized clinical trial. JAMA 2015;314(13):1356–63. DOI: 10.1001/jama.2015.12009.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">15. Penna M., Hompes R., Arnold S. et al. Transanal Total Mesorectal Excision: International Registry Results of the First 720 Cases. Ann Surg 2016 Oct 4. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="ru">Penna M., Hompes R., Arnold S. et al. Transanal Total Mesorectal Excision: International Registry Results of the First 720 Cases. Ann Surg 2016 Oct 4. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">16. Staderini F., Foppa C., Minuzzo A. et al. Robotic rectal surgery: State of the art. World J Gastrointest Oncol 2016;8(11): 757–71. DOI: 10.4251/wjgo.v8.i11.757. PMID: 27895814.</mixed-citation><mixed-citation xml:lang="ru">Staderini F., Foppa C., Minuzzo A. et al. Robotic rectal surgery: State of the art. World J Gastrointest Oncol 2016;8(11): 757–71. DOI: 10.4251/wjgo.v8.i11.757. PMID: 27895814.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">17. Ito M., Sugito M., Kobayashi A. et al. Relationship between multiple numbers of stapler firings during rectal division and anastomotic leakage after laparoscopic rectal resection. Int J Color Dis 2008;23(7):703–7. DOI: 10.1007/s00384-008-0470-8.</mixed-citation><mixed-citation xml:lang="ru">Ito M., Sugito M., Kobayashi A. et al. Relationship between multiple numbers of stapler firings during rectal division and anastomotic leakage after laparoscopic rectal resection. Int J Color Dis 2008;23(7):703–7. DOI: 10.1007/s00384-008-0470-8.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">18. Lacy A.M., Tasende M.M., Delgado S. et al. Transanal total mesorectal excision for rectal cancer: outcomes after 140 patients. J Am Coll Surg 2015;221(2):415–23. DOI: 10.1016/j.jamcollsurg.2015.03.046.</mixed-citation><mixed-citation xml:lang="ru">Lacy A.M., Tasende M.M., Delgado S. et al. Transanal total mesorectal excision for rectal cancer: outcomes after 140 patients. J Am Coll Surg 2015;221(2):415–23. DOI: 10.1016/j.jamcollsurg.2015.03.046.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">19. Penna M., Knol J.J., Tuynman J.B. et al. Four anastomotic techniques following transanal total mesorectal excision (TaTME). Tech Coloproctol 2016;20(3):185–91. DOI: 10.1007/s10151-015-1414-2.</mixed-citation><mixed-citation xml:lang="ru">Penna M., Knol J.J., Tuynman J.B. et al. Four anastomotic techniques following transanal total mesorectal excision (TaTME). Tech Coloproctol 2016;20(3):185–91. DOI: 10.1007/s10151-015-1414-2.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
