Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press17310.17650/2220-3478-2016-6-2-40-46ORIGINAL REPORTSОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯОтдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишкиMad’yarovZh. M.МадьяровЖ. М.
Russian Federation
arsen69@list.ruRasulovA. O.РасуловА. О.
Russian Federation
BarsukovYu. A.БарсуковЮ. А.
Russian Federation
TkachevS. I.ТкачевС. И.
Russian Federation
Kuz’michevD. V.КузьмичевД. В.
Russian Federation
GordeevS. S.ГордеевС. С.
Russian Federation
MalikhovA. G.МалиховА. Г.
Russian Federation
FedyaninM. Yu.ФедянинМ. Ю.
Russian Federation
Department of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of RussiaОтделение проктологии ФГБУ «РОНЦ им. Н. Н. Блохина» Минздрава Росссии23 Kashirskoe Shosse, Moscow, 115478, RussiaРоссия, 115478, Москва, Каширское шоссе, 23Department Radiation Oncology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russiaотделение радиационной онкологии ФГБУ «РОНЦ им. Н. Н. Блохина» Минздрава РосссииDepartment of ProctologyОтделение проктологии ФГБУ «РОНЦ им. Н. Н. Блохина» Минздрава РосссииРоссия, 115478, Москва, Каширское шоссе, 23Department of Clinical Pharmacology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia23 Kashirskoe Shosse, Moscow, 115478, Russiaотделение клинической фаракологии ФГБУ «РОНЦ им. Н. Н. Блохина» Минздрава РосссииРоссия, 115478, Москва, Каширское шоссе, 23050820166240460508201605082016Copyright ©; 2016, ABV-pressCopyright ©; 2016, АБВ-пресс2016ABV-pressАБВ-прессhttps://onco-surgery.info/jour/about/editorialPolicieshttps://onco-surgery.info/jour/article/view/173

Background. Сomparative assessment of long-term oncologic outcomes of surgical and combined treatment of patients with upper rectal cancer.

Materials and methods. Patients aged > 18 with histologycally verified upper T1–4N0–2M0 rectal cancer were included. In group A patients received neoadjuvant chemoradiotherapy 25 Gy in 5 Gy fractions with capecitabine 850 mg/m2 bid per os on radiation days and surgery. In group B patients received surgery alone.

Results. From january 2004 to december 2014, we selected 227 archival cases of patients with upper rectal cancer. Group A was 103 patients (45.4 %) in group B – 123 (54.6 %). We traced long-term results of treatment in 217 (96.6 %) patients. In the group A was 98 (95.1 %) patients, in the group B – 119 (96.7 %) patients. Local recurrence occurred in group A – 1 (1.2 %) patient, in group B – 3 (2.5 %) patients (p = 0.413). The frequency of distant metastases developed in group A in 10 (10.2 %) patients and in group B – 15 (12.6 %) patients (p = 0.581). Overall survival in group A was 90.6 %, and the disease-free survival – 89.6 %, in group B – 82.8 % and 81.9 %, respectively (p = 0.46).

Conclusions. Surgical treatment of patients with upper rectal cancer stage I–III, in compliance with all oncological principles is justified.

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