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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Surgery and Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Surgery and Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Хирургия и онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="electronic">2949-5857</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">168</article-id><article-id pub-id-type="doi">10.17650/2220-3478-2016-6-2-8-17</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Factors associated with the efficiency of maintenance therapy in patients with metastatic colorectal cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Факторы, ассоциированные с эффективностью поддерживающей химиотерапии при метастатическом раке толстой кишки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedyanin</surname><given-names>M. Yu.</given-names></name><name xml:lang="ru"><surname>Федянин</surname><given-names>М. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>fedianinmu@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tryakin</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Трякин</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Polyanskaya</surname><given-names>E. M.</given-names></name><name xml:lang="ru"><surname>Полянская</surname><given-names>Е. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pokataev</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Покатаев</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sheina</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Сехина</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kozlov</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Козлов</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Strogonova</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Строгонова</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gordeev</surname><given-names>S. S.</given-names></name><name xml:lang="ru"><surname>Гордеев</surname><given-names>С. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kuz’michev</surname><given-names>D. V.</given-names></name><name xml:lang="ru"><surname>Кузьмичев</surname><given-names>Д. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Aliev</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Алиев</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sagaydak</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Сагайдак</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rasulov</surname><given-names>S. A.</given-names></name><name xml:lang="ru"><surname>Расулов</surname><given-names>А. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tyulandin</surname><given-names>S. A.</given-names></name><name xml:lang="ru"><surname>Тюляндин</surname><given-names>С. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">23 Kashirskoe shosse, Moscow, 115478, Russia</institution></aff><aff><institution xml:lang="ru">Россия, 115478, Москва, Каширское шоссе, 23</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-08-05" publication-format="electronic"><day>05</day><month>08</month><year>2016</year></pub-date><volume>6</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>8</fpage><lpage>17</lpage><history><date date-type="received" iso-8601-date="2016-08-05"><day>05</day><month>08</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-08-05"><day>05</day><month>08</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Fedyanin M.Y., Tryakin A.A., Polyanskaya E.M., Pokataev I.A., Sheina O.V., Kozlov N.A., Strogonova A.M., Gordeev S.S., Kuz’michev D.V., Aliev V.A., Sagaydak I.V., Rasulov S.A., Tyulandin S.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, Федянин М.Ю., Трякин А.А., Полянская Е.М., Покатаев И.А., Сехина О.В., Козлов Н.А., Строгонова А.М., Гордеев С.С., Кузьмичев Д.В., Алиев В.А., Сагайдак И.В., Расулов А.О., Тюляндин С.А.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Fedyanin M.Y., Tryakin A.A., Polyanskaya E.M., Pokataev I.A., Sheina O.V., Kozlov N.A., Strogonova A.M., Gordeev S.S., Kuz’michev D.V., Aliev V.A., Sagaydak I.V., Rasulov S.A., Tyulandin S.A.</copyright-holder><copyright-holder xml:lang="ru">Федянин М.Ю., Трякин А.А., Полянская Е.М., Покатаев И.А., Сехина О.В., Козлов Н.А., Строгонова А.М., Гордеев С.С., Кузьмичев Д.В., Алиев В.А., Сагайдак И.В., Расулов А.О., Тюляндин С.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://onco-surgery.info/jour/article/view/168">https://onco-surgery.info/jour/article/view/168</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>colon cancer</kwd><kwd>unresectable metastases</kwd><kwd>maintenance chemotherapy</kwd><kwd>first-line therapy</kwd><kwd>second-line therapy</kwd><kwd>progression-free survival</kwd><kwd>fluoropyrimidines</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак толстой кишки</kwd><kwd>неоперабельные метастазы</kwd><kwd>поддерживающая химиотерапия</kwd><kwd>терапия 1-й линии</kwd><kwd>терапия 2-й линии</kwd><kwd>выживаемость без прогрессирования</kwd><kwd>фторпиримидины</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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