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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Surgery and Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Surgery and Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Хирургия и онкология</trans-title></trans-title-group></journal-title-group><issn publication-format="electronic">2949-5857</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">149</article-id><article-id pub-id-type="doi">10.17650/2220-3478-2015-5-4-24-30</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Oral fluorpyrimidines in preoperative chemoradiotherapy for operable rectal cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Пероральные фторпиримидины в предоперационной химиолучевой терапии больных операбельным раком прямой кишки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Barsukov</surname><given-names>Yu. A.</given-names></name><name xml:lang="ru"><surname>Барсуков</surname><given-names>Ю. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tkachyov</surname><given-names>S. I.</given-names></name><name xml:lang="ru"><surname>Ткачёв</surname><given-names>С. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Malikhov</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Малихов</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gordeev</surname><given-names>S. S.</given-names></name><name xml:lang="ru"><surname>Гордеев</surname><given-names>С. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><email>ss.netoncology@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Perevoshchikov</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Перевощиков</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Aliev</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Алиев</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kuz'michyov</surname><given-names>D. V.</given-names></name><name xml:lang="ru"><surname>Кузьмичёв</surname><given-names>Д. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tataev</surname><given-names>I. Sh.</given-names></name><name xml:lang="ru"><surname>Татаев</surname><given-names>И. Ш.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mad'yarov</surname><given-names>Zh. M.</given-names></name><name xml:lang="ru"><surname>Мадьяров</surname><given-names>Ж. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ovchinnikova</surname><given-names>A. I.</given-names></name><name xml:lang="ru"><surname>Овчинникова</surname><given-names>А. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kovalyova</surname><given-names>Yu. Yu.</given-names></name><name xml:lang="ru"><surname>Ковалёва</surname><given-names>Ю. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>23 Kashirskoe Shosse, Moscow, 115478</p></bio><bio xml:lang="ru"><p>115478, Москва, Каширское шоссе, 23</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-01-16" publication-format="electronic"><day>16</day><month>01</month><year>2016</year></pub-date><volume>5</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>24</fpage><lpage>30</lpage><history><date date-type="received" iso-8601-date="2016-01-15"><day>15</day><month>01</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-01-15"><day>15</day><month>01</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Barsukov Y.A., Tkachyov S.I., Malikhov A.G., Gordeev S.S., Perevoshchikov A.G., Aliev V.A., Kuz'michyov D.V., Tataev I.S., Mad'yarov Z.M., Ovchinnikova A.I., Kovalyova Y.Y.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, Барсуков Ю.А., Ткачёв С.И., Малихов А.Г., Гордеев С.С., Перевощиков А.Г., Алиев В.А., Кузьмичёв Д.В., Татаев И.Ш., Мадьяров Ж.М., Овчинникова А.И., Ковалёва Ю.Ю.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Barsukov Y.A., Tkachyov S.I., Malikhov A.G., Gordeev S.S., Perevoshchikov A.G., Aliev V.A., Kuz'michyov D.V., Tataev I.S., Mad'yarov Z.M., Ovchinnikova A.I., Kovalyova Y.Y.</copyright-holder><copyright-holder xml:lang="ru">Барсуков Ю.А., Ткачёв С.И., Малихов А.Г., Гордеев С.С., Перевощиков А.Г., Алиев В.А., Кузьмичёв Д.В., Татаев И.Ш., Мадьяров Ж.М., Овчинникова А.И., Ковалёва Ю.Ю.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://onco-surgery.info/jour/article/view/149">https://onco-surgery.info/jour/article/view/149</self-uri><abstract xml:lang="en"><p><bold>Background.</bold> The aim of this study was to compare short and long-term outcomes after neoadjuvant short-course chemoradiotherapy with capecitabine ot tegafur for operable rectal cancer.</p><p><bold>Materials and methods.</bold> Patients with histologycally verified Т3N0M0, Т2–3N1–2M0 rectal cancer, who underwent 5 × 5 Gy neoadjuvant radiotherapy with local 41–45 °C hyperthermia on days 3–5 and metronidazole 10 g/m2 per rectum days 3, 5 were randomized to receive capecitabine 1000 mg/m2 bid per os days 1–14 or tegafur 400 mg/m2 bid per os days 1–21. Toxicity, tumor regression, sphincter preservation rate and long-term outcomes were analyzed.</p><p><bold>Results.</bold> During 2011–2013 26 patients were included in the tegafur group and 30 – in capecitabine group. Overall toxicity was 50 % in the tegafur arm and 36.7 % in the capecitabine arm (p = 0.42), grade III–IV toxicity (diarrhoea was the most common grade 3+ event) was observed in 23.1 % and 6.7 % (p = 0.13) patients accordingly. Grade III–IV tumor regression was observed in 34.6 % patients, who received tegafur and 53.3 % (p = 0.12) patients who received capecitabine. Sphincter-sparing surgery was performed in 84.6 % and 100 % (p = 0.04) patients who received tegafur and capecitabine accordingly. Median follow-up was 31.6 and 32.2 months accordingly. 3-year overall survival in capecitabine and tegafur arms was 95.4 and 82.1 % (р = 0.13), 3-year disease-free survival – 91 and 74 % (р = 0.029).</p><p><bold>Conclusions.</bold> Both fluorpyrimidines demonstrated comparable short-term outcomes with a tendency to better results in the capecitabine arm.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>rectal cancer</kwd><kwd>chemoradiotherapy</kwd><kwd>fluorpyrimidines</kwd><kwd>capecitabine</kwd><kwd>tegafur</kwd><kwd>sphincter-sparing surgery</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак прямой кишки</kwd><kwd>химиолучевая терапия</kwd><kwd>фторпиримидины</kwd><kwd>капецитабин</kwd><kwd>тегафур</kwd><kwd>сфинктеросохраняющие операции</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. van Gijn W., Marijnen C.A., Nagtegaal I.D. et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol 2011;12(6):575–82.</mixed-citation><mixed-citation xml:lang="ru">van Gijn W., Marijnen C.A., Nagtegaal I.D. et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol 2011;12(6):575–82.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Folkesson J., Birgisson H., Pahlman L. et al. Swedish Rectal Cancer Trial: long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol 2005;23(24):5644–50.</mixed-citation><mixed-citation xml:lang="ru">Folkesson J., Birgisson H., Pahlman L. et al. Swedish Rectal Cancer Trial: long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol 2005;23(24):5644–50.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Sebag-Montefiore D., Stephens R.J., Steele R. et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC–CTG C016): a multicentre, randomised trial. Lancet 2009;373(9666):811–20.</mixed-citation><mixed-citation xml:lang="ru">Sebag-Montefiore D., Stephens R.J., Steele R. et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC–CTG C016): a multicentre, randomised trial. Lancet 2009;373(9666):811–20.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Quirke P., Steele R., Monson J. et al. Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet 2009;373(9666):821–8.</mixed-citation><mixed-citation xml:lang="ru">Quirke P., Steele R., Monson J. et al. Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet 2009;373(9666):821–8.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Koukourakis M.I., Simopoulos C., Pitiakoudis M. et al. Hypofractionated accelerated radiotherapy, cytoprotection and capecitabine in the treatment of rectal cancer: a feasibility study. Anticancer Res 2008;28(5B): 3035–40.</mixed-citation><mixed-citation xml:lang="ru">Koukourakis M.I., Simopoulos C., Pitiakoudis M. et al. Hypofractionated accelerated radiotherapy, cytoprotection and capecitabine in the treatment of rectal cancer: a feasibility study. Anticancer Res 2008;28(5B): 3035–40.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Gray L.H., Conger A.D., Ebert M. et al. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953;26(312):638–48.</mixed-citation><mixed-citation xml:lang="ru">Gray L.H., Conger A.D., Ebert M. et al. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953;26(312):638–48.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Дарьялова С.Л., Поляков П.Ю., Киселева Е.С. и др. Метронидазол при лучевом лечении злокачественных новообразований. Медицинская радиология 1986;(7):6–13. [Dar, yalova S.L., Polyakov P.Yu., Kiseleva Е.S. et al. Меtronidazole in the radiation therapy of malignant tumors. Meditsinskaya radiologiya = Меdical Radiology 1986;(7): 6–13. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Дарьялова С.Л., Поляков П.Ю., Киселева Е.С. и др. Метронидазол при лучевом лечении злокачественных новообразований. Медицинская радиология 1986;(7):6–13. [Dar, yalova S.L., Polyakov P.Yu., Kiseleva Е.S. et al. Меtronidazole in the radiation therapy of malignant tumors. Meditsinskaya radiologiya = Меdical Radiology 1986;(7): 6–13. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Coleman C.N., Turrisi A.T. Radiation and chemotherapy sensitizers and protectors. Crit Rev Oncol Hematol 1990;10(3):225–52.</mixed-citation><mixed-citation xml:lang="ru">Coleman C.N., Turrisi A.T. Radiation and chemotherapy sensitizers and protectors. Crit Rev Oncol Hematol 1990;10(3):225–52.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Бердов Б.А., Невольских А.А., Ерыгин Д.В., Титова Л.Н. Лечение местнораспространенного рака прямой кишки. Вопросы онкологии 2007;5(53):578–83. [Berdov B.А., Nevol, skikh А.А., Еrygin D.V., Тitova L.N. Treatment of the local rectal cancer. Voprosy onkologii = Oncology Issues 2007;5(53):578–83. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Бердов Б.А., Невольских А.А., Ерыгин Д.В., Титова Л.Н. Лечение местнораспространенного рака прямой кишки. Вопросы онкологии 2007;5(53):578–83. [Berdov B.А., Nevol, skikh А.А., Еrygin D.V., Тitova L.N. Treatment of the local rectal cancer. Voprosy onkologii = Oncology Issues 2007;5(53):578–83. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Ерыгин Д.В., Бердов Б.А., Невольских A.A. и др. Местно-распространенный рак прямой кишки – пути улучшения результатов лечения. В сб.: Материалы I съезда колопроктологов СНГ. Ташкент, 2009. С. 149–50. [Еrygin D.V., Berdov B.А., Nevol, skikh A.A. et al. Local rectal cancer – ways of treatment results, improvement. In: Маterials of the I conference of CIS coloproctologists. Таshkent, 2009. Рр. 149–50. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Ерыгин Д.В., Бердов Б.А., Невольских A.A. и др. Местно-распространенный рак прямой кишки – пути улучшения результатов лечения. В сб.: Материалы I съезда колопроктологов СНГ. Ташкент, 2009. С. 149–50. [Еrygin D.V., Berdov B.А., Nevol, skikh A.A. et al. Local rectal cancer – ways of treatment results, improvement. In: Маterials of the I conference of CIS coloproctologists. Таshkent, 2009. Рр. 149–50. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Голдобенко Г.В. Лучевая терапия в клинической онкологии: достижения, проблемы и перспективы. Вестник РОНЦ им. Н.Н. Блохина РАМН 1999;10(1):3–7. [Goldobenko G.V. Radial therapy in clinical oncology: achievements, problems and prospects. Vestnik RONC im. N.N. Blokhina RAMN = Herald of N.N. Blokhin Russian Cancer Research Center of RAMS. 1999;10(1):3–7. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Голдобенко Г.В. Лучевая терапия в клинической онкологии: достижения, проблемы и перспективы. Вестник РОНЦ им. Н.Н. Блохина РАМН 1999;10(1):3–7. [Goldobenko G.V. Radial therapy in clinical oncology: achievements, problems and prospects. Vestnik RONC im. N.N. Blokhina RAMN = Herald of N.N. Blokhin Russian Cancer Research Center of RAMS. 1999;10(1):3–7. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Ткачев С.И., Нечушкин М.И., Юрьева Т.В. и др. Развитие методов лучевого лечения в начале XXI века в ГУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН. Вестник Российской академии медицинских наук 2007;(10):9–13. [Тkachev S.I., Nechushkin М.I., Yur, eva Т.V. et al. Development of radial treatment methods in the beginning of the XXI century in the SE N.N. Blokhin Russian Cancer Research Center RAMS. Vestnik Rossiyskoy akademii meditsinskih nauk = Herald of the Russian Academy of Medical Science 2007;(10):9–13. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Ткачев С.И., Нечушкин М.И., Юрьева Т.В. и др. Развитие методов лучевого лечения в начале XXI века в ГУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН. Вестник Российской академии медицинских наук 2007;(10):9–13. [Тkachev S.I., Nechushkin М.I., Yur, eva Т.V. et al. Development of radial treatment methods in the beginning of the XXI century in the SE N.N. Blokhin Russian Cancer Research Center RAMS. Vestnik Rossiyskoy akademii meditsinskih nauk = Herald of the Russian Academy of Medical Science 2007;(10):9–13. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Steel G.G. The search for therapeutic gain in the combination of radiotherapy and chemotherapy. Radiother Oncol 1988;11(1):31–53.</mixed-citation><mixed-citation xml:lang="ru">Steel G.G. The search for therapeutic gain in the combination of radiotherapy and chemotherapy. Radiother Oncol 1988;11(1):31–53.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Steel G.G., Peckham M.J. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys 1979;5(1):85–91.</mixed-citation><mixed-citation xml:lang="ru">Steel G.G., Peckham M.J. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys 1979;5(1):85–91.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Кныш В.И. Клиническое течение, диагностика и современное состояние лечения рака прямой кишки. Автореф. дис. … д-ра мед. наук. М., 1979. [Knysh V.I. Clinical treatment, diagnosis and modern status of the rectal cancer treatment. Аuthor,</mixed-citation><mixed-citation xml:lang="ru">Кныш В.И. Клиническое течение, диагностика и современное состояние лечения рака прямой кишки. Автореф. дис. … д-ра мед. наук. М., 1979. [Knysh V.I. Clinical treatment, diagnosis and modern status of the rectal cancer treatment. Аuthor,</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><mixed-citation>s abstract of thesis … of doctor of medical sciences. Мoscow, 1979. (In Russ.)].</mixed-citation></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">16. Bosset J.F., Calais G., Mineur L. et al. Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results – EORTC 22921. J Clin Oncol 2005;23(24):5620–7.</mixed-citation><mixed-citation xml:lang="ru">Bosset J.F., Calais G., Mineur L. et al. Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results – EORTC 22921. J Clin Oncol 2005;23(24):5620–7.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">17. Bosset J.F., Collette L., Calais G. et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006;355(11):1114–23.</mixed-citation><mixed-citation xml:lang="ru">Bosset J.F., Collette L., Calais G. et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006;355(11):1114–23.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">18. Gérard J.P., Conroy T., Bonnetain F. et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3–4 rectal cancers: results of FFCD 9203. J Clin Oncol 2006;24(28):4620–5.</mixed-citation><mixed-citation xml:lang="ru">Gérard J.P., Conroy T., Bonnetain F. et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3–4 rectal cancers: results of FFCD 9203. J Clin Oncol 2006;24(28):4620–5.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">19. Rischin D., Peters L., Fisher R. et al. Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). J Clin Oncol 2005;23(1):79–87.</mixed-citation><mixed-citation xml:lang="ru">Rischin D., Peters L., Fisher R. et al. Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). J Clin Oncol 2005;23(1):79–87.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">20. Kjellström J., Kjellén E., Johnsson A. In vitro radiosensitization by oxaliplatin and 5-fluorouracil in a human colon cancer cell line. Acta Oncol 2005;44(7):687–93.</mixed-citation><mixed-citation xml:lang="ru">Kjellström J., Kjellén E., Johnsson A. In vitro radiosensitization by oxaliplatin and 5-fluorouracil in a human colon cancer cell line. Acta Oncol 2005;44(7):687–93.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">21. Barsukov Y.A., Gordeyev S.S., Tkachev S.I. et al. Phase II study</mixed-citation><mixed-citation xml:lang="ru">Barsukov Y.A., Gordeyev S.S., Tkachev S.I. et al. Phase II study</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><mixed-citation>of concomitant chemoradiotherapy with local hyperthermia and metronidazole for locally advanced fixed rectal cancer. Colorectal Dis 2013;15(9):1107–14.</mixed-citation></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">22. Ярмоненко С.П. Полирадиомодификация как новый подход к повышению эффективности лучевой терапии опухолей. В кн.: Радиомодификаторы в лучевой терапии опухолей. Обнинск, 1982. С. 126–7. [Yarmonenko S.P. Polyradiomodification as new approach to the enhancement of the efficiance of the radial therapy of tumors. In: Radiomodificators in the radial therapy of tumors. Оbninsk, 1982. Pp. 126–7. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Ярмоненко С.П. Полирадиомодификация как новый подход к повышению эффективности лучевой терапии опухолей. В кн.: Радиомодификаторы в лучевой терапии опухолей. Обнинск, 1982. С. 126–7. [Yarmonenko S.P. Polyradiomodification as new approach to the enhancement of the efficiance of the radial therapy of tumors. In: Radiomodificators in the radial therapy of tumors. Оbninsk, 1982. Pp. 126–7. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">23. Hahn G.M., Shiu E.C. Effect of pH and elevated temperatures on the cytotoxicity of some chemotherapeutic agents on Chinese hamster cells in vitro. Cancer Res 1983; 43(12 Pt 1):5789–91.</mixed-citation><mixed-citation xml:lang="ru">Hahn G.M., Shiu E.C. Effect of pH and elevated temperatures on the cytotoxicity of some chemotherapeutic agents on Chinese hamster cells in vitro. Cancer Res 1983; 43(12 Pt 1):5789–91.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">24. Miller R.C., Richards M., Baird C. et al. Interaction of hyperthermia and chemotherapy agents; cell lethality and oncogenic potential. Int J Hyperthermia 1994;10(1):89–99.</mixed-citation><mixed-citation xml:lang="ru">Miller R.C., Richards M., Baird C. et al. Interaction of hyperthermia and chemotherapy agents; cell lethality and oncogenic potential. Int J Hyperthermia 1994;10(1):89–99.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">25. Takemoto M., Kuroda M., Urano M. et al. The effect of various chemotherapeutic agents given with mild hyperthermia on different types of tumours. Int J Hyperthermia 2003;19(2):193–203.</mixed-citation><mixed-citation xml:lang="ru">Takemoto M., Kuroda M., Urano M. et al. The effect of various chemotherapeutic agents given with mild hyperthermia on different types of tumours. Int J Hyperthermia 2003;19(2):193–203.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">26. Meyer D.E., Kong G.A., Dewhirst M.W. et al. Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia. Cancer Res 2001;61(4):1548–54.</mixed-citation><mixed-citation xml:lang="ru">Meyer D.E., Kong G.A., Dewhirst M.W. et al. Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia. Cancer Res 2001;61(4):1548–54.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">27. Ohno S., Siddik Z.H., Kido Y. et al. Thermal enhancement of drug uptake and DNA adducts as a possible mechanism for the effect of sequencing hyperthermia on cisplatininduced cytotoxicity in L1210 cells. Cancer Chemother Pharmacol 1994;34(4):302–6.</mixed-citation><mixed-citation xml:lang="ru">Ohno S., Siddik Z.H., Kido Y. et al. Thermal enhancement of drug uptake and DNA adducts as a possible mechanism for the effect of sequencing hyperthermia on cisplatininduced cytotoxicity in L1210 cells. Cancer Chemother Pharmacol 1994;34(4):302–6.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">28. Fujiwara K., Kohno I., Sekiba K. Therapeutic effect of hyperthermia combined with chemotherapy on vulvar and vaginal carcinoma. Acta Med Okayama 1987;41(2):55–62.</mixed-citation><mixed-citation xml:lang="ru">Fujiwara K., Kohno I., Sekiba K. Therapeutic effect of hyperthermia combined with chemotherapy on vulvar and vaginal carcinoma. Acta Med Okayama 1987;41(2):55–62.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">29. de la Torre A., García-Berrocal M.I., Arias F. et al. Preoperative chemoradiotherapy for rectal cancer: randomized trial comparing oral uracil and tegafur and oral leucovorin vs. intravenous 5-fluorouracil and leucovorin. Int J Radiat Oncol Biol Phys 2008;70(1):102–10.</mixed-citation><mixed-citation xml:lang="ru">de la Torre A., García-Berrocal M.I., Arias F. et al. Preoperative chemoradiotherapy for rectal cancer: randomized trial comparing oral uracil and tegafur and oral leucovorin vs. intravenous 5-fluorouracil and leucovorin. Int J Radiat Oncol Biol Phys 2008;70(1):102–10.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">30. Glynne-Jones R., Dunst J., SebagMontefiore D. The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been? Ann Oncol 2006;17(3):361–71.</mixed-citation><mixed-citation xml:lang="ru">Glynne-Jones R., Dunst J., SebagMontefiore D. The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been? Ann Oncol 2006;17(3):361–71.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">31. Kim J.S., Kim J.S., Cho M.J. et al. Comparison of the efficacy of oral capecitabine versus bolus 5-FU in preoperative radiotherapy of locally advanced rectal cancer. J Korean Med Sci 2006;21(1):52–7.</mixed-citation><mixed-citation xml:lang="ru">Kim J.S., Kim J.S., Cho M.J. et al. Comparison of the efficacy of oral capecitabine versus bolus 5-FU in preoperative radiotherapy of locally advanced rectal cancer. J Korean Med Sci 2006;21(1):52–7.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">32. Byfield J.E. 5-Fluorouracil radiation sensitization – a brief review. Invest New Drugs 1989;7(1):111–6.</mixed-citation><mixed-citation xml:lang="ru">Byfield J.E. 5-Fluorouracil radiation sensitization – a brief review. Invest New Drugs 1989;7(1):111–6.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">33. Ojima E., Inoue Y., Watanabe H. et al. The optimal schedule for 5-fluorouracil radiosensitization in colon cancer cell lines. Oncol Rep 2006;16(5):1085–91.</mixed-citation><mixed-citation xml:lang="ru">Ojima E., Inoue Y., Watanabe H. et al. The optimal schedule for 5-fluorouracil radiosensitization in colon cancer cell lines. Oncol Rep 2006;16(5):1085–91.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">34. Sawada N., Ishikawa T., Sekiguchi F. et al. X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts. Clin Cancer Res 1999;5(10):2948–53.</mixed-citation><mixed-citation xml:lang="ru">Sawada N., Ishikawa T., Sekiguchi F. et al. X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts. Clin Cancer Res 1999;5(10):2948–53.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">35. Lawrence T.S., Burke R., Davis M.A. Lack of effect of TP53 status on fluorodeoxyuridinemediated radiosensitization. Radiat Res 2000;154(2):140–4.</mixed-citation><mixed-citation xml:lang="ru">Lawrence T.S., Burke R., Davis M.A. Lack of effect of TP53 status on fluorodeoxyuridinemediated radiosensitization. Radiat Res 2000;154(2):140–4.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">36. Hwang H.S., Davis T.W., Houghton J.A. et al. Radiosensitivity of thymidylate synthasedeficient human tumor cells is affected by progression through the G1 restriction point into S-phase: implications for fluoropyrimidine radiosensitization. Cancer Res 2000;60(1):92–100.</mixed-citation><mixed-citation xml:lang="ru">Hwang H.S., Davis T.W., Houghton J.A. et al. Radiosensitivity of thymidylate synthasedeficient human tumor cells is affected by progression through the G1 restriction point into S-phase: implications for fluoropyrimidine radiosensitization. Cancer Res 2000;60(1):92–100.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">37. Davis M.A., Tang H.Y., Maybaum J., Lawrence T.S. Dependence of fluorodeoxyuridine-mediated radiosensitization on S phase progression. Int J Radiat Biol 1995;67(5):509–17.</mixed-citation><mixed-citation xml:lang="ru">Davis M.A., Tang H.Y., Maybaum J., Lawrence T.S. Dependence of fluorodeoxyuridine-mediated radiosensitization on S phase progression. Int J Radiat Biol 1995;67(5):509–17.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">38. Lawrence T.S., Davis M.A., Loney T.L. Fluoropyrimidine-mediated radiosensitization depends on cyclin E-dependent kinase activation. Cancer Res 1996;56(14):3203–6.</mixed-citation><mixed-citation xml:lang="ru">Lawrence T.S., Davis M.A., Loney T.L. Fluoropyrimidine-mediated radiosensitization depends on cyclin E-dependent kinase activation. Cancer Res 1996;56(14):3203–6.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">39. Yoshikawa R., Kusunoki M., Yanagi H. et al. Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: a novel target mechanism concept for pharmacokinetic modulating chemotherapy. Cancer Res 2001;61(3):1029–37.</mixed-citation><mixed-citation xml:lang="ru">Yoshikawa R., Kusunoki M., Yanagi H. et al. Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: a novel target mechanism concept for pharmacokinetic modulating chemotherapy. Cancer Res 2001;61(3):1029–37.</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">40. Олтаржевская Н.Д. Патент № 2352359 «Способ создания композиции для доставки лекарственного препарата в полости организма при заболеваниях». [Оltarzhevskaya N.D. Patent № 2352359 “Method of creation of a composition for the pharmaceutical delivery to the organism cavity at diseases”. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Олтаржевская Н.Д. Патент № 2352359 «Способ создания композиции для доставки лекарственного препарата в полости организма при заболеваниях». [Оltarzhevskaya N.D. Patent № 2352359 “Method of creation of a composition for the pharmaceutical delivery to the organism cavity at diseases”. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">41. Кныш В.И., Ткачев С.И., Перевощиков А.Г. и др. Лечение рака прямой кишки с использованием нескольких радиомодификаторов при предоперационной лучевой терапии. Медицинская радиология и радиационная безопасность 2008;(2):25–30. [Knysh V.I., Тkachev S.I., Perevoshchikov А.G. et al. Treatment of the rectal cancer with use of several radiomodificators at the pre-surgery radial therapy. Meditsinskaya radiologiya i radiatsionnaya bezopasnost, = Меdical Radiology and Radiation Security 2008; (2):25–30. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Кныш В.И., Ткачев С.И., Перевощиков А.Г. и др. Лечение рака прямой кишки с использованием нескольких радиомодификаторов при предоперационной лучевой терапии. Медицинская радиология и радиационная безопасность 2008;(2):25–30. [Knysh V.I., Тkachev S.I., Perevoshchikov А.G. et al. Treatment of the rectal cancer with use of several radiomodificators at the pre-surgery radial therapy. Meditsinskaya radiologiya i radiatsionnaya bezopasnost, = Меdical Radiology and Radiation Security 2008; (2):25–30. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">42. Ngan S.Y., Burmeister B., Fisher R.J. et al. Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: trans-tasman radiation oncology group trial 01.04. J Clin Oncol 2012;30(31):3827–33.</mixed-citation><mixed-citation xml:lang="ru">Ngan S.Y., Burmeister B., Fisher R.J. et al. Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: trans-tasman radiation oncology group trial 01.04. J Clin Oncol 2012;30(31):3827–33.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">43. Bujko K., Nowacki M.P., Nasierowska-Guttmejer A. et al. Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg 2006;93(10):1215–23.</mixed-citation><mixed-citation xml:lang="ru">Bujko K., Nowacki M.P., Nasierowska-Guttmejer A. et al. Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg 2006;93(10):1215–23.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">44. Beppu N., Matsubara N., Noda M. et al. The timing of surgery after preoperative short-course S-1 chemoradiotherapy with delayed surgery for T3 lower rectal cancer. Int J Colorectal Dis 2014;29(12): 1459–66.</mixed-citation><mixed-citation xml:lang="ru">Beppu N., Matsubara N., Noda M. et al. The timing of surgery after preoperative short-course S-1 chemoradiotherapy with delayed surgery for T3 lower rectal cancer. Int J Colorectal Dis 2014;29(12): 1459–66.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">45. Aschele C., Cionini L., Lonardi S. et al. Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial. J Clin Oncol 2011;29(2): 2773–80.</mixed-citation><mixed-citation xml:lang="ru">Aschele C., Cionini L., Lonardi S. et al. Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial. J Clin Oncol 2011;29(2): 2773–80.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">46. Rödel C., Liersch T., Becker H. et al. Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol 2012;13(7):679–87.</mixed-citation><mixed-citation xml:lang="ru">Rödel C., Liersch T., Becker H. et al. Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol 2012;13(7):679–87.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
