Surgery and OncologySurgery and OncologyХирургия и онкология2949-5857Publishing House ABV Press13910.17650/2220-3478-2015-5-3-15-24REVIEWОБЗОРЫ ЛИТЕРАТУРЫRole of stem cells in large bowel carcinogenesisРоль стволовых клеток в канцерогенезе толстой кишкиNefedovaN. A.НефёдоваН. А.
Russian Federation
ale_x_05@mail.ruMal,kovP. G.МальковП. Г.
Russian Federation
M. V. Lomonosov Moscow State UniversityФГБОУ ВО «Московский государственный университет им. М. В. Ломоносова»Bldg. 5, 31 Lomonosovskiy Prosp., Moscow, 119192, RussiaРоссия, 119192, Москва, Ломоносовский просп., 31, корп. 5081020155315240810201508102015Copyright ©; 2015, Nefedova N.A., Mal,kov P.G.Copyright ©; 2015, Нефёдова Н.А., Мальков П.Г.2015Nefedova N.A., Mal,kov P.G.Нефёдова Н.А., Мальков П.Г.https://creativecommons.org/licenses/by/4.0https://onco-surgery.info/jour/article/view/139

Сancer stem cells (CSC) play a significant role in the development and progression of colorectal cancer. They are capable of self-senewal and multipotent differentiation. CSC can be formed from stem cells or mutant by dedifferentiation of crypt epithelial cells. Recently, much attention is paid to CSC in colon cancer, but very little has been published regarding their expression in colon polyps. In 2010 The World Health Organization attributed the so-called serrated lesions, including hyperplastic polyp, serrated sessile adenoma and traditional serrated adenoma to a group of precancerous lesions of the colon in addition to the classical tubular, villous and tubulo-villous adenomas. Despite the large number of publications devoted to the newly selected category, a full understanding of the processes involved in the formation of polyps and their progression into colon cancer, there is still no. Identification of CSC in colon polyps will assess their potential malignancy conduct adequate therapy, determine the amount of the operation and further treatment strategy. This in turn will contribute to the early detection and prevention of cancer. Identification of CSC, an assessment of their localization and distribution in tubular adenomas, serrated adenoma broad-based, traditional serrated adenoma and hyperplastic polyps allow to evaluate the potential of malignancy and prognosis for each of the polyps. In this regard, the definition of markers characteristic of colon CSC, is interesting not only from a scientific, but also from a practical point of view.

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