Email this article BIOLOGICAL MARKERS OF RECTAL CANCER NEOADJUVANT CHEMORADIOTHERAPY EFFICACY
- Authors: Fedyanin M.Y.1, Tryakin A.A.1, Tjulandin S.A.1
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Affiliations:
- N.N. Blokhin Russian Cancer Research Center,Russian Academy of Medical Sciences, Moscow
- Issue: Vol 2, No 4 (2013)
- Pages: 12-22
- Section: REVIEW
- Published: 01.03.2015
- URL: https://onco-surgery.info/jour/article/view/98
- DOI: https://doi.org/10.17650/2220-3478-2013-0-4-12-22
- ID: 98
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Abstract
Combination of neoadjuvant chemoradiotherapy and surgery is the basic treatment for locally advanced rectal tumors. Despite that, a subgroup of patients does not benefit from combined treatment. A wide search of biological markers predicting neoadjuvant chemoradiotherapy efficacy is currently conducted. Tumor cell signal pathways are investigated (EGFR, Wnt), cell cycle and apoptosis, tumor stroma. Several studies with DNA microarray analysis were conducted. Predictive value of these biological markers is reviewed in this article.
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About the authors
M. Yu. Fedyanin
N.N. Blokhin Russian Cancer Research Center,Russian Academy of Medical Sciences, Moscow
Author for correspondence.
Email: fedianinmu@mail.ru
Department of Clinical Pharmacology and Chemotherapy Russian Federation
A. A. Tryakin
N.N. Blokhin Russian Cancer Research Center,Russian Academy of Medical Sciences, Moscow
Email: fedianinmu@mail.ru
Department of Clinical Pharmacology and Chemotherapy Russian Federation
S. A. Tjulandin
N.N. Blokhin Russian Cancer Research Center,Russian Academy of Medical Sciences, Moscow
Email: fedianinmu@mail.ru
Department of Clinical Pharmacology and Chemotherapy Russian Federation
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