Email this article INTERSPHINCTERIC RESECTIONS FOR LOW RECTAL CANCER WITH ANORECTAL REGION INVOLVEMENT
- Authors: Barsukov Y.A.1, Perevoshchikov A.G.1, Kuzmichev D.V.1, Аliyev V.A.1, Malikhov A.G.1, Tatayev I.S.1, Balyasnikova S.S.1, Polynovskiy A.V.1
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Affiliations:
- N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
- Issue: Vol 2, No 4 (2013)
- Pages: 34-41
- Section: ORIGINAL REPORTS
- Published: 01.03.2015
- URL: https://onco-surgery.info/jour/article/view/91
- DOI: https://doi.org/10.17650/2220-3478-2013-0-4-34-41
- ID: 91
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Abstract
Preoperative chemoradiotherapy and surgery for low rectal cancer involving anorectal region are discussed in this article.
Subjects .and .methods . 42 patients were included in this study, 18 received neoadjuvant chemoradiotherapy 5 × 5 Gy and 24 had chemo-radiotherapy up to 40 Gy in 4 Gy fractions.
Results . Treatment had acceptable toxicity levels with grade III toxicity of 11.1 % and 8.3 % accordingly. 20.8 % had pathological complete response following 40 Gy chemoradiotherapy. 22.2 % patients in 5 × 5 Gy group had intershinctering resections comparing to 75 % patients in 40 Gy group. No local or distant recurrences were observed with a median followup of 42.9 months and 18.1 months accordingly.
Conclusions . Developed treatment scheme have high efficacy, improving surgery ablastics and leading to good long-term outcome, improving sphincter preservation rate and patients quality of life.
About the authors
Yu. A. Barsukov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Author for correspondence.
Email: oncopro@gmail.com
Russian Federation
A. G. Perevoshchikov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: oncopro@gmail.com
Russian Federation
D. V. Kuzmichev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: oncopro@gmail.com
Russian Federation
V. A. Аliyev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: oncopro@gmail.com
Russian Federation
A. G. Malikhov
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: oncopro@gmail.com
Russian Federation
I. Sh. Tatayev
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: oncopro@gmail.com
Russian Federation
S. S. Balyasnikova
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: oncopro@gmail.com
Russian Federation
A. V. Polynovskiy
N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow
Email: oncopro@gmail.com
Russian Federation
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