External beam radiation therapy for cell carcinoma of the anal canal: preparation, planning, details of treatment

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Abstract

In the absence of a unified approach in numerous recommendations and consensuses for chemoradiotherapy of patients with squamous cell non-metastatic anal canal cancer, medical practitioners need a practical consolidating “tool” combining all information sources, which is the purpose of this article.

Based on international recommendations and consensuses on radiation therapy, the expert group analyzed the data and compiled the most optimal approaches to target volume delineation. This was done based on a balanced analysis of the advantages and disadvantages of the fractionation modes used and the criteria for dose distribution in irradiated apparatus proposed by both other authors and the team of the radiotherapy department of the N. N. Blokhin National Medical Research Center of Oncology. Examples of delineating anatomical structures and target volumes are provided.

About the authors

M. V. Chernykh

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-4944-4035

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

V. A. Uymanov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0001-9853-215X

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

D. V. Kurenkov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Author for correspondence.
Email: dokerdk@gmail.com
ORCID iD: 0009-0003-9587-3794

Dmitry Valeryevich Kurenkov,

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

V. A. Ivanov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-3028-7578

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

E. V. Alieva

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0009-0005-5670-9451

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

E. A. Romanova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-0101-512X

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

E. A. Zavistovsky

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0009-0000-8480-7765

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

O. A. Mironova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0009-0002-6250-2957

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

T. A. Kryilova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0009-0003-9844-3589

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

References

  1. Gordeev S.S., Besova N.S., Mamedli Z.Z. et al. Practical recommendations for the treatment of anal canal cancer and skin of the perianal area. Practical recommendations RUSSCO. Zlokachestvennye opukholi = Malignant Tumours 2022;12(3s2-1):455–66. (In Russ.). doi: 10.18027/2224-5057-2022-12-3s2-455-466
  2. Ng M., Leong T., Chander S. et al. Australasian Gastro Intestinal Trials Group (AGITG) contouring atlas and planning guidelines for intensity-modulated radiotherapy in anal cancer. Int J Radiation Oncol Biol Phys 2012;83(5):1455–62. doi: 10.1016/j.ijrobp.2011.12.058
  3. Myerson R.J., Garofalo M.C., El Naqa I. et al. Elective clinical target volumes for conformal therapy in anorectal cancer: a radiation therapy oncology group consensus panel contouring atlas. Int J Radiat Oncol Biol Phys 2009;74:824–30. doi: 10.1016/j.ijrobp.2008.08.070
  4. Valentini V., Gambacorta M.A., Barbaro B. et al. International consensus guidelines on clinical target volume delineation in rectal cancer. Radiother Oncol 2016;120:195–201. doi: 10.1016/j.radonc.2016.07.017
  5. Dapper H., Schiller K., Münch S. et al. Have we achieved adequate recommendations for target volume definitions in anal cancer? A PET imaging-based patterns of failure analysis in the context of established contouring guidelines. BMC Cancer 2019;19(1):742. doi: 10.1186/s12885-019-5970-0

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