Prognosis of early and advanced signet ring cell gastric carcinoma compared with other histological subtypes

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Abstract

Background. Signet ring cell gastric carcinoma of the stomach traditionally characterized by its poor prognosis. Survival of patients with signet ring cell gastric carcinoma regardless of the stage of the disease has not been well studied.

Aim. To compare clinicopathological characteristics and survival of the patients with signet ring cell gastric carcinoma of the stomach and non-signet ring cell carcinoma depending on the stage of the disease.

Materials and methods. We performed retrospective review was undertaken of patients with gastric cancer who received surgical treatment in period from 2013–2018.

Results. At early signet ring cell cancer, the 3and 5-year survival rates was 100,0 and 89.0 %; for non-signet ring cell carcinoma 91.4 and 85.3 % (р = 0.6; Hazard Ratio (HR) 0.73; 95 % Confidence Interval (CI) 0.22–2.42) respectively. For advanced signet ring cell carcinoma, the median survival rates, 3and 5-year survival rates was 38 months, 53.0 and 38.4 %; for non-signet ring cell carcinoma 51.1 months, 59.2 and 48.0 % (р = 0.2; HR 1.2; 95 % CI 0.91–1.54).

Conclusion. Long-term results in patients with early (T1) signet ring cell cancer of the stomach did not significantly differ in comparison with other histological types of gastric cancer. Long-term results of advanced signet ring cell cancer are worse than non-signet ring cell cancer, but the differences are not statistically significant.

About the authors

R. O. Torosyan

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Author for correspondence.
Email: rf.torosyan97@gmail.com
ORCID iD: 0009-0003-9711-5620

Rafael Oganesovich Torosyan 

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

S. N. Nered

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia;
Russian Medical Academy of Continuous Professional Education, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-5403-2396

24 Kashirskoe Shosse, Moscow 115522,

2/1 Barricadnaya St., Moscow 123995

Russian Federation

N. A. Kozlov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-3852-3969

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

Henian Sun

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0001-5574-0047

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

P. V. Kononets

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-4744-6141

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

I S. Stilidi

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-5229-8203

24 Kashirskoe Shosse, Moscow 115522,

1 Ostrovityanova St., Moscow 11799

Russian Federation

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