Gardner’s syndrome (literature review and case report)

Cover Page

Cite item

Full Text

Abstract

Gardner’s syndrome is a genetically determined disease characterized by a combination of colon polyposis, osteomas, and various soft tissue tumors. In this article, we discuss disease epidemiology, etiology, manifestations, and treatment methods. We also report a case of Gardner’s syndrome.

About the authors

I. L. Chernikovskiy

Department of Oncological Coloproctology, Moscow Cancer Hospital No. 62, Moscow Healthcare Department

Author for correspondence.
27, Istra, Krasnogorsk district, Moscow region 143423 Russian Federation

D. N. Korobkov

Department of Oncological Coloproctology, Moscow Cancer Hospital No. 62, Moscow Healthcare Department

27, Istra, Krasnogorsk district, Moscow region 143423 Russian Federation

N. V. Savanovich

Department of Oncological Coloproctology, Moscow Cancer Hospital No. 62, Moscow Healthcare Department

27, Istra, Krasnogorsk district, Moscow region 143423 Russian Federation

D. A. Chernikov

Department of Oncological Coloproctology, Moscow Cancer Hospital No. 62, Moscow Healthcare Department

27, Istra, Krasnogorsk district, Moscow region 143423 Russian Federation

P. V. Melnikov

Department of Oncological Coloproctology, Moscow Cancer Hospital No. 62, Moscow Healthcare Department

27, Istra, Krasnogorsk district, Moscow region 143423 Russian Federation

A. V. Gavrilyukov

Department of Oncological Coloproctology, Moscow Cancer Hospital No. 62, Moscow Healthcare Department

27, Istra, Krasnogorsk district, Moscow region 143423 Russian Federation

References

  1. Koh K.J., Park H.N., Kim K.A. Gardner syndrome associated with multiple osteomas, intestinal polyposis, and epidermoid cysts. Imaging Sci Dent 2016;46(4):267–72. doi: 10.5624/isd.2016.46.4.267.
  2. Agrawal D., Newaskar V., Shrivastava S., Anand Nayak P. External manifestations of Gardner’s syndrome as the presenting clinical entity. BMJ Case Rep 2014;2014:bcr2013200293. doi: 10.1136/bcr-2013-200293.
  3. Panjwani S., Bagewadi A., Keluskar V., Arora S. Gardner’s syndrome. J Clin Imaging Sci 2011;1:65. doi: 10.4103/2156-7514.92187.
  4. Gardner E.J. A genetic and clinical study of intestinal polyposis: a predisposing factor for carcinoma of the colon and rectum. Am J Hum Genet 1951;3:167–76.
  5. Gardner E.J., Richards R.C. Multiple cutaneous and sub-cutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. Am J Hum Genet 1952;5:139–47.
  6. Smud D., Augustin G., Kekez T. et al. Gardner’s syndrome: genetic testing and colonoscopy are indicated in adolescents and young adults with cranial osteomas: a case report. World J Gastroenterol 2007;13(28):3900–3.
  7. Черни Э. Синдром Гарднера. Офтальмологические ведомости 2013;6(1):82–3. [Cherni E. Gardner’s syndrome. Oftalmologicheskie vedomosti = Ophthalmology journal 2013;6(1):82–3. (In Russ.)].
  8. Verma P., Surya V., Kadam S., Umarji H.R. Classical presentation of Gardner’s syndrome in an Indian patient: A case report. Contemp Clin Dent 2016;7(2):277–80. doi: 10.4103/0976-237X.183063.
  9. Bertario L., Presciuttini S., Sala P. et al. Causes of death and postsurgical survival in familial adenomatous polyposis: results from the Italian Registry. Italian Registry of Familial Polyposis Writing Committee. Surg Oncol 1994;10(3):225–34.
  10. Bülow S. Results of national registration of familial adenomatous polyposis. Gut 2003;52(5):742–6.
  11. Herzig D.O., Buie W.D., Weiser M.R. et al. Clinical practice guidelines for the surgical treatment of patients with lynch syndrome. Dis Colon Rectum 2017;60(2):137–43. doi: 10.1097/DCR.0000000000000785.
  12. Шелыгин Ю.А., Багдасарян Л.К., Благодарный Л.А. Клинические рекомендации по диагностике и лечению взрослых пациентов с семейным аденоматозом толстой кишки. М., 2013. 16 с. Доступно по: http://www.gnck.ru/ rec/recommendation_satk.pdf. [Shelygin Yu.A., Bagdasaryan L.K., Blagodarniy L.A. Clinical guideline for the diagnosis and treatment of adult patients with familial adenomatosis of the colon. Moscow, 2013. 16 p. Available at: http://www.gnck.ru/rec/ recommendation_satk.pdf. (In Russ.)].
  13. Syngal S., Brand R.E., Church J.M. et al. ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol 2015;110(2):223–63. doi: 10.1038/ajg.2014.435.
  14. Balmaña J., Balaguer F., Cervantes A., Arnold D. Familial risk-colorectal cancer: ESMO Clinical Practice Guidelines.
  15. Ann Oncol 2013;24(Suppl 6):vi73–80. doi: 10.1093/annonc/mdt209.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2020 Chernikovskiy I.L., Korobkov D.N., Savanovich N.V., Chernikov D.A., Melnikov P.V., Gavrilyukov A.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77-85909 от  25.08.2023.