Role of adjuvant chemotherapy in patients with rectal cancer after preoperative chemoradiotherapy: results of a retrospective study

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M. Yu. Fedyanin

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Author for correspondence.
Email: fedianinmu@mail.ru
ORCID iD: 0000-0001-5615-7806
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

Kh. Kh.-M. El’sunkaeva

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

I. A. Pokataev

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

A. A. Tryakin

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-2245-214X
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

A. A. Bulanov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

O. V. Sekhina

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

D. A. Chekini

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

E. O. Ignatova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

S. S. Gordeev

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-9303-8379
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

V. A. Aliev

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0003-2245-214X
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

D. V. Kuzmichev

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

Z. Z. Mamedli

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

M. V. Chernykh

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

V. V. Glebovskaya

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

S. I. Tkachev

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

N. A. Kozlov

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

S. A. Tjulandin

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0001-9807-2229
23 Kashirskoe Shosse, Moscow 115478 Russian Federation

References

  1. Fedyanin M.Yu., Tryakin A.A., Tlulandin S.A. Adjuvant chemotherapy after chemoradiotherapy for locally advanced rectal cancer. Onkologicheskaya koloproktologiya = Colorectal Oncology 2014;(2):5–12. (In Russ.).
  2. Rectal cancer. NCCN Clinical Practical Guidelines in Oncology. Version 3.2017. Available at: http://www.nccn.org/professionals/physician_gls/pdf/rectal.pdf.
  3. Glynne-Jones R., Wyrwicz L., Tiret E. et al. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2017;28(Suppl 4):iv22–40. PMID: 28881920. doi: 10.1093/annonc/mdx224.
  4. Poulsen L.O., Qvortrup C., Pfeiffer P. et al. Review on adjuvant chemotherapy for rectal cancer why do treatment guidelines differ so much? Acta Oncol 2015;54(4):437–46. PMID: 25597332. doi: 10.3109/0284186X.2014.993768.
  5. [Gordeev S.S. Variants of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer. Summary of thesis … of candidate of medical sciences. Moscow, 2013. (In Russ.).
  6. Aliev V.A. Choosing an optimal treatment strategy in colorectal cancer patients with synchronous distant metastases. Summary of thesis … of doctor of medical sciences. Moscow, 2015. (In Russ.).
  7. Govindarajan A., Reidy D., Weiser M.R. et al. Recurrence rates and prognostic factors in ypN0 rectal cancer after neoadjuvant chemoradiation and total mesorectal excision. Ann Surg Oncol 2011;18(13):3666–72. PMID: 21590450. doi: 10.1245/s10434-011-1788-y.
  8. Das P., Skibber J.M., Rodriguez-Bigas M.A. et al. Clinical and pathologic predictors of locoregional recurrence, distant metastasis and overall survival in patients treated with chemoradiation and mesorectal excision for rectal cancer. Am J Clin Oncol 2006;29(3):219–24. PMID: 16755173. doi: 10.1097/01. coc.0000214930.78200.4a.
  9. Janjan N.A., Crane C., Feig B.W. et al. Improved overall survival among responders to preoperative chemoradiation for locally advanced rectal cancer. Am J Clin Oncol 2001;24(2):107–12. PMID: 11319280
  10. Glynne-Jones R., Councell N., Meadows M. et al. CHRONICLE: a phase III trail in locally advanced rectal cancer after neoadjuvant chemoradiation randomizing postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control. Ann Oncol 2014;25(7):1356–62. PMID: 24718885. doi: 10.1093/annonc/mdu147.
  11. Reinel H., Schäßburger K., Meyer D. et al. 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) as postoperative adjuvant chemotherapy (CT) for node-positive rectal cancer after radiochemotherapy (R-CT) and surgery. J Clin Oncol 2010;28(Suppl 15):e14125. doi: 10.1200/jco.2010.28.15_suppl.e14125.
  12. Hofheinz R.D., Wenz F., Post S. et al. Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial. Lancet Oncol 2012;13(6):579–88. PMID: 22503032. doi: 10.1016/S1470-2045(12)70116-X.
  13. Ngan S.Y., Burmeister B., Fisher R.J. et al. Randomised trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group Trial 01.04. J Clin Oncol 2012;30:3827–33. PMID: 23008301. doi: 10.1200/JCO.2012.42.9597.
  14. Maas M., Nelemans P.J., Valentini V. et al. Adjuvant chemotherapy in rectal cancer: defining subgroups who may benefit after neoadjuvant chemoradiation and resection: a pooled analysis of 3 313 patients. Int J Cancer 2015;137(1):212–20. PMID: 25418551. doi: 10.1002/ijc.29355.
  15. Polanco P.M., Mokdad A.A., Zhu H. et al. Association of adjuvant chemotherapy with overall survival in patients with rectal cancer and pathologic complete response following neoadjuvant chemotherapy and resection. JAMA Oncol 2018. PMID: 29710272. doi: 10.1001/jamaoncol.2018.0231.
  16. Hong Y.S., Nam B.H., Jung K.H. et al. Adjuvant chemotherapy with oxaliplatin/5fluorouracil/leucovorin (FOLFOX) versus 5-fluorouracil/leucovorin (FL) in patients with locally advanced rectal cancer after preoperative chemoradiotherapy followed by surgery: a randomized phase II study (The ADORE). J Clin Oncol 2013;31(Suppl):abstr.3570.
  17. Rӧdel C., Liersch T., Becker H. et al. Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initia results of the German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol 2012;13(7):679–87. PMID: 22627104ю doi: 10.1016/S14702045(12)70187-0
  18. Gresham G., Speers C., Woods R. et al. Association of time to adjuvant chemotherapy (TTAC) and overall survival among patients with rectal cancer treated with preoperative radiation. J Clin Oncol 2013;31(4 Suppl):461. doi: 10.1200/jco.2013.31.4_suppl.461.

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