Email this article Localization of the primary tumor of the colon: аre there essential differences?
- Authors: Fedyanin M.Y.1, Tryakin A.A.1, Tjulandin S.A.1
-
Affiliations:
- N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
- Issue: Vol 7, No 3 (2017)
- Pages: 35-48
- Section: REVIEW
- Published: 07.12.2017
- URL: https://onco-surgery.info/jour/article/view/225
- DOI: https://doi.org/10.17650/2220-3478-2017-7-3-35-48
- ID: 225
Cite item
Full Text
Abstract
Colon cancer is a heterogenous disease with each subtype having a distinct clinical picture and, consequently, different prognosis. Therefore, the tumors can be classified according to their localization: as emerging from the left or right side of the colon. The proximal and distal colon have different embryogenesis which determines the boundary between the right and left colon at the level of the distal margin of the middle third of the colon. In literature, there’s enough data to consider other differences apart from embryogenesis. Right- and left-side colon tumors differ epidemiologically, clinically and pathomorphologically, molecularly and genetically. This, presumably, explains differences in screening, prevention, and treatment of these tumors. The objective of this review is to analyze differences between colon tumors with different localizations and to determine if such subdivision of colon cancer in clinical practice affects treatment and prevention approaches.
About the authors
M. Yu. Fedyanin
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: fedianinmu@mail.ru
23 Kashirskoe Shosse, Moscow 115478, Russia Russian Federation
A. A. Tryakin
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478, Russia Russian Federation
S. A. Tjulandin
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
23 Kashirskoe Shosse, Moscow 115478, Russia Russian Federation
References
Supplementary files
