Email this article Отдаленные результаты хирургического и комбинированного лечения больных раком верхнеампулярного отдела прямой кишки
- Authors: Mad’yarov Z.M.1,2, Rasulov A.O.1,2, Barsukov Y.A.1,2, Tkachev S.I.3,2, Kuz’michev D.V.1,2, Gordeev S.S.1,2, Malikhov A.G.4, Fedyanin M.Y.5,2
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Affiliations:
- Department of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia
- 23 Kashirskoe Shosse, Moscow, 115478, Russia
- Department Radiation Oncology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia
- Department of Proctology
- Department of Clinical Pharmacology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia
- Issue: Vol 6, No 2 (2016)
- Pages: 40-46
- Section: ORIGINAL REPORTS
- Published: 05.08.2016
- URL: https://onco-surgery.info/jour/article/view/173
- DOI: https://doi.org/10.17650/2220-3478-2016-6-2-40-46
- ID: 173
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Abstract
Background. Сomparative assessment of long-term oncologic outcomes of surgical and combined treatment of patients with upper rectal cancer.
Materials and methods. Patients aged > 18 with histologycally verified upper T1–4N0–2M0 rectal cancer were included. In group A patients received neoadjuvant chemoradiotherapy 25 Gy in 5 Gy fractions with capecitabine 850 mg/m2 bid per os on radiation days and surgery. In group B patients received surgery alone.
Results. From january 2004 to december 2014, we selected 227 archival cases of patients with upper rectal cancer. Group A was 103 patients (45.4 %) in group B – 123 (54.6 %). We traced long-term results of treatment in 217 (96.6 %) patients. In the group A was 98 (95.1 %) patients, in the group B – 119 (96.7 %) patients. Local recurrence occurred in group A – 1 (1.2 %) patient, in group B – 3 (2.5 %) patients (p = 0.413). The frequency of distant metastases developed in group A in 10 (10.2 %) patients and in group B – 15 (12.6 %) patients (p = 0.581). Overall survival in group A was 90.6 %, and the disease-free survival – 89.6 %, in group B – 82.8 % and 81.9 %, respectively (p = 0.46).
Conclusions. Surgical treatment of patients with upper rectal cancer stage I–III, in compliance with all oncological principles is justified.
About the authors
Zh. M. Mad’yarov
Department of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, Russia
Author for correspondence.
Email: arsen69@list.ru
Russian Federation
A. O. Rasulov
Department of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, Russia
Email: fake@neicon.ru
Russian Federation
Yu. A. Barsukov
Department of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, Russia
Email: fake@neicon.ru
Russian Federation
S. I. Tkachev
Department Radiation Oncology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, Russia
Email: fake@neicon.ru
Russian Federation
D. V. Kuz’michev
Department of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, Russia
Email: fake@neicon.ru
Russian Federation
S. S. Gordeev
Department of Proctology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, Russia
Email: fake@neicon.ru
Russian Federation
A. G. Malikhov
Department of Proctology
Email: fake@neicon.ru
Russian Federation
M. Yu. Fedyanin
Department of Clinical Pharmacology N. N. Blokhin Russian Cancer Research Center of the Ministry of Health of Russia; 23 Kashirskoe Shosse, Moscow, 115478, Russia
Email: fake@neicon.ru
Russian Federation
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